In the published article, there was an error in the Figure 7 legend as published. The figure legend effect size values were incorrectly displayed as “>1.25, 51.5, 51.75, 52” instead of “>1.25, ≥1.5, ≥1.75, ≥2”. The corrected Figure 7 and its caption appear below.
Figure 7
Relative power by sample size, effect size, and sequencing depth at each post-vaccination day as simulated using the modified PROPER R package. Days were sorted by decreasing vaccination effect based on overall fold changes and DEG responses observed for this study (see Figure 3A). Power was assessed for different fold-change cutoffs (indicated by color-coded lines), sequencing depth (as indicated by the line type), and sample size (x-axis).
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Statements
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
RNA-Seq, statistical power, ERCC, tularemia vaccine (DVC-LVS), gene filtering, sequencing depth, read length, reproducibility
Citation
Goll JB, Bosinger SE, Jensen TL, Walum H, Grimes T, Tharp GK, Natrajan MS, Blazevic A, Head RD, Gelber CE, Steenbergen KJ, Patel NB, Sanz P, Rouphael NG, Anderson EJ, Mulligan MJ and Hoft DF (2023) Corrigendum: The Vacc-SeqQC project: Benchmarking RNA-Seq for clinical vaccine studies. Front. Immunol. 14:1163550. doi: 10.3389/fimmu.2023.1163550
Received
10 February 2023
Accepted
13 February 2023
Published
23 February 2023
Approved by
Frontiers Editorial Office, Frontiers Media SA, Switzerland
Volume
14 - 2023
Updates
Copyright
© 2023 Goll, Bosinger, Jensen, Walum, Grimes, Tharp, Natrajan, Blazevic, Head, Gelber, Steenbergen, Patel, Sanz, Rouphael, Anderson, Mulligan and Hoft.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Daniel F. Hoft, Daniel.Hoft@health.slu.edu; Mark J. Mulligan, mark.mulligan@nyulangone.org
†These authors have contributed equally to this work
This article was submitted to Systems Immunology, a section of the journal Frontiers in Immunology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.