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CORRECTION article

Front. Immunol., 19 December 2025

Sec. Inflammation

Volume 16 - 2025 | https://doi.org/10.3389/fimmu.2025.1744810

Correction: FKBP5-CCL5 interaction promotes neuroinflammation and neuronal apoptosis in ischemic stroke by regulating the MAPK pathway and enhancing NET formation

This article is a correction to:

  1. FKBP5-CCL5 interaction promotes neuroinflammation and neuronal apoptosis in ischemic stroke by regulating the MAPK pathway and enhancing NET formation

    1. Read original article
Zhongchen Li&#x;Zhongchen Li1†Tengkun Yin,&#x;Tengkun Yin1,2†Hongyang GuoHongyang Guo1Zhenxing LiuZhenxing Liu1Peijian WangPeijian Wang1Chao LiuChao Liu1Qingbo WangQingbo Wang1Meng ZhangMeng Zhang1Yilei XiaoYilei Xiao1Jiyue Wang*Jiyue Wang1*Jiheng Hao*Jiheng Hao1*Liyong Zhang*Liyong Zhang1*
  • 1Department of Neurosurgery, Liaocheng People’s Hospital, Liaocheng, Shandong, China
  • 2Department of Neurosurgery, Qilu Hospital and Institute of Brain and Brain-Inspired Science, Cheeloo College of Medicine, Shandong University, Shandong, China

A Correction on
FKBP5-CCL5 interaction promotes neuroinflammation and neuronal apoptosis in ischemic stroke by regulating the MAPK pathway and enhancing NET formation

By Li Z, Yin T, Guo H, Liu Z, Wang P, Liu C, Wang Q, Zhang M, Xiao Y, Wang J, Hao J and Zhang L (2025) Front. Immunol. 16:1609989. doi: 10.3389/fimmu.2025.1609989

Affiliation “Department of Neurosurgery, Qilu Hospital and Institute of Brain and Brain-Inspired Science, Cheeloo College of Medicine, Shandong University, Shandong, China” was omitted for author “Tengkun Yin”. This affiliation has now been added for author “Tengkun Yin”.

Also, there was a mistake in Figure 7B as published. Upon reviewing the published version, we noticed that Figure 7B was inadvertently placed error, which was the same as Figure 7A. The corrected Figure 7B appears below.

Figure 7
Bar graphs labeled A, B, C, and D show statistical comparisons across six experimental groups: Oe-NC, Oe-FKBP5, si-NC, si-CCL5, si-CCL5+oe-FKBP5, and Oe-FKBP5+AZD6244. Graph A depicts TNFα levels, B shows IL-1β, C presents MPO-DNA complex, and D illustrates H3cit. Statistical significance is indicated with p-values below 0.0001 and 0.0004 for different comparisons.

Figure 7. Influence of FKBP5 on BV2 cell polarization and neutrophil NETs formation via the p38 MAPK signaling pathway. Levels of pro-inflammatory cytokines, TNFα (A) and IL-1β (B), were quantified using ELISA in different groups. Levels of NET markers, MPO-DNA (C) and H3cit (D), were quantified using ELISA in different groups. AZD6244 is an inhibitor of the MAPK pathway. n = 3.

The original version of this article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: ischemic stroke, FKBP5, CCL5, NET, MAPK

Citation: Li Z, Yin T, Guo H, Liu Z, Wang P, Liu C, Wang Q, Zhang M, Xiao Y, Wang J, Hao J and Zhang L (2025) Correction: FKBP5-CCL5 interaction promotes neuroinflammation and neuronal apoptosis in ischemic stroke by regulating the MAPK pathway and enhancing NET formation. Front. Immunol. 16:1744810. doi: 10.3389/fimmu.2025.1744810

Received: 12 November 2025; Accepted: 11 December 2025;
Published: 19 December 2025.

Edited and reviewed by:

Yaping Yan, Shaanxi Normal University, China

Copyright © 2025 Li, Yin, Guo, Liu, Wang, Liu, Wang, Zhang, Xiao, Wang, Hao and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Jiheng Hao, aGFvamloZW5nQDE2My5jb20=; Liyong Zhang, MTMzNDYyNTY5MzZAMTYzLmNvbQ==; Jiyue Wang, aml5dWV3YW5nQDE2My5jb20=

†These authors share first authorship

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.