Where and when bacterial chromosome replication starts: a single cell perspective
- 1University of Wrocław, Poland
Bacterial chromosomes have a single, unique replication origin (named oriC), from which DNA synthesis starts. This study describes methods of visualizing oriC regions and the chromosome replication in single living bacterial cells in real-time. This review also discusses the impact of live cell imaging techniques on understanding of chromosome replication dynamics, particularly at the initiation step, in different species of bacteria.
Keywords: Replication initiation, single-cell, bacterial chromosome, oriC, replisome
Received: 30 Sep 2018;
Accepted: 02 Nov 2018.
Edited by:Feng Gao, Tianjin University, China
Reviewed by:Julia Grimwade, Florida Institute of Technology, United States
Christian J. Rudolph, Brunel University London, United Kingdom
Copyright: © 2018 Trojanowski, Hołówka and Zakrzewska-Czerwinska. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Jolanta Zakrzewska-Czerwinska, University of Wrocław, Wrocław, 50-137, Silesian, Poland, email@example.com