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Front. Microbiol. | doi: 10.3389/fmicb.2018.02819

Where and when bacterial chromosome replication starts: a single cell perspective

Damian Trojanowski1, Joanna Hołówka1 and  Jolanta Zakrzewska-Czerwinska1*
  • 1University of Wrocław, Poland

Bacterial chromosomes have a single, unique replication origin (named oriC), from which DNA synthesis starts. This study describes methods of visualizing oriC regions and the chromosome replication in single living bacterial cells in real-time. This review also discusses the impact of live cell imaging techniques on understanding of chromosome replication dynamics, particularly at the initiation step, in different species of bacteria.

Keywords: Replication initiation, single-cell, bacterial chromosome, oriC, replisome

Received: 30 Sep 2018; Accepted: 02 Nov 2018.

Edited by:

Feng Gao, Tianjin University, China

Reviewed by:

Julia Grimwade, Florida Institute of Technology, United States
Christian J. Rudolph, Brunel University London, United Kingdom  

Copyright: © 2018 Trojanowski, Hołówka and Zakrzewska-Czerwinska. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Jolanta Zakrzewska-Czerwinska, University of Wrocław, Wrocław, 50-137, Silesian, Poland,