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Arbovirus Interactions and Human Disease

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Front. Microbiol. | doi: 10.3389/fmicb.2019.00022

Arbovirus-Mosquito Vector-Host Interactions and the Impact on Transmission and Disease Pathogenesis of Arboviruses

Yan-Jang S. Huang1, Stephen Higgs1 and  Dana L. Vanlandingham1*
  • 1Kansas State University, United States

Hundreds of viruses, designated as arboviruses, are transmitted by arthropod vectors in complex transmission cycles between the virus, vertebrate host, and the vector. With millions of human and animal infections per year, it is critical to improve our understanding of the interactions between the biological and environmental factors that play a critical role in pathogenesis, disease outcomes, and transmission of arboviruses. This review focuses on mosquito-borne arboviruses and discusses current knowledge of the factors and underlying mechanisms that influence infection and transmission of arboviruses and discusses critical factors and pathways that can potentially become targets for intervention and therapeutics.

Keywords: Arthropod Vectors, Arboviruses, vertebrate hosts, Infection, transmission

Received: 31 Oct 2018; Accepted: 09 Jan 2019.

Edited by:

Tonya M. Colpitts, National Emerging Infectious Diseases Laboratories (NEIDL),Boston University, United States

Reviewed by:

Saravanan Thangamani, The University of Texas Medical Branch at Galveston, United States
Stephen Wikel, Quinnipiac University, United States  

Copyright: © 2019 Huang, Higgs and Vanlandingham. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Dana L. Vanlandingham, Kansas State University, Manhattan, 66506, Kansas, United States,