Original Research ARTICLE
Alterations in Gut Microbiota by Statin Therapy and Possible Intermediate Effects on Hyperglycemia and Hyperlipidemia
- 1Sahmyook University, South Korea
- 2Chungbuk National University, South Korea
Dysbiosis of the gut microbiota is a contributing factor for obesity-related metabolic diseases such as hyperglycemia and hyperlipidemia. Pharmacotherapy for metabolic diseases involves the modulation of gut microbiota, which is suggested to be a potential therapeutic target. In this study, the modulation of gut microbiota by statins (cholesterol-lowering drugs: atorvastatin and rosuvastatin) was investigated in an aged mouse model of high-fat diet-induced obesity, and the association between gut microbiota and immune responses was described. Atorvastatin and rosuvastatin significantly increased the abundance of the genera Bacteroides, Butyricimonas, and Mucispirillum. Moreover, the abundance of these genera was correlated with the inflammatory response, including levels of IL-1β and TGFβ1 in the ileum. In addition, oral fecal microbiota transplantation with fecal material collected from rosuvastatin-treated mouse groups improved the hyperglycemia. From these results, the effect of statins on metabolic improvements could be explained by altered gut microbiota. Our findings suggest that the modulation of gut microbiota by statins has an important role in the therapeutic actions of these drugs.
Keywords: Gut microbiota (GM), Short-chain fatty acid (SCFA), Atorvastatin (AT), Rosuvastatin (RSV), IL-1β, TGFβ1
Received: 16 Mar 2019;
Accepted: 08 Aug 2019.
Edited by:Yuheng Luo, Sichuan Agricultural University, China
Reviewed by:Natasa Golic, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia
Monica Di Paola, University of Florence, Italy
Copyright: © 2019 Lee, Kim, An, Song, Lee, Kim and Hyunseok. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Kong Hyunseok, Sahmyook University, Seoul, South Korea, firstname.lastname@example.org