In the original article, there was a mistake in the caption for
Figure 4Aas published. The incorrect caption stated NCM460 cell lines are normal gastric epithelial cells, however, NCM460 cell lines are normal colorectal epithelial cells. The correct caption for
Figure 4appears below. Additionally, there was a mistake in
Figure 1as published. Figure 1C is immunofluorescence and
Figure 1Dis immunocomplex by Co-IP. OE-ControlTrop2 should appear on the top row and OE-Trop2 should appear on the bottom row in
Figure 1C. Representative images for these parts contain small issues which have been corrected. The corrected
Figure 1appears below.
FIGURE 4. The effects of CORO1C knockdown on CRC growth and metastasis in vitro and in vivo. (A) Levels of CORO1C1 protein expression in CRC cell lines and normal colorectal epithelial cells (NCM460) determined by western blotting. (B) COCA2 and HCT116 cells showed a significant decrease in protein level after shCORO1C transfection. (C) CORO1C downregulation significantly inhibited the proliferation of both cell lines. (D) A significant decrease in cell anchorage-dependent growth was detected after CORO1C knockdown. (E, F) Decreased CORO1C expression impaired abilities of migration (E) and invasion (F) of CRC cells (scale bar, 150 μm). All quantitative data of invitro assays were generated from three replicates (G). The effects of CORO1C downregulation on the tumor growth in the xenograft mouse model (n = 6 mice/per group). *p < 0.05, **p < 0.01, ***p < 0.001.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
FIGURE 1
Associations between CORO1C, TROP2, and CRC metastasis. Overexpression of Trop2 in 293T cells was confirmed by (A) qRT-PCR, (B) Western blotting, and (C) Immunofluorescence. (D) Trop2 immunocomplex by Co-IP; (E) Heatmap of proteins interacting with Trop2 in PC and MC. The RNA-seq data were obtained from GSE28702. Red and green colors represent high and low gene expression, respectively. PC: primary CRC; MC: metastatic CRC, **p < 0.01.
Statements
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
CORO1C, colorectal cancer, prognosis, metastasis, Akt
Citation
Wang Z, Jia L, Yushu sun, Li C, Zhang L, Wang X and Chen H (2021) Corrigendum: CORO1C is Associated with Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer. Front. Mol. Biosci. 8:727347. doi: 10.3389/fmolb.2021.727347
Received
18 June 2021
Accepted
14 July 2021
Published
30 August 2021
Volume
8 - 2021
Edited by
Haishi Qiao, China Pharmaceutical University, China
Reviewed by
Ern Yu Tan, Tan Tock Seng Hospital, Singapore
Updates
Copyright
© 2021 Wang, Jia, Yushu sun, Li, Zhang, Wang and Chen.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Xiangcheng Wang, guyan@nmgfy.com; Hao Chen, ha0chen@wnmc.edu.cn
This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.