%A Zuloaga,Damian %A Jacobskind,Jason %A Raber,Jacob %D 2015 %J Frontiers in Neuroscience %C %F %G English %K Methamphetamine,stress,Anxiety,substance abuse,Glucocorticoids,HPA axis %Q %R 10.3389/fnins.2015.00178 %W %L %M %P %7 %8 2015-May-27 %9 Mini Review %+ Dr Damian Zuloaga,University at Albany,Department of Psychology,1400 Washington Ave,Albany,12222,NY,United States,dzuloaga@albany.edu %# %! Methamphetamine HPA Axis %* %< %T Methamphetamine and the hypothalamic-pituitary-adrenal axis %U https://www.frontiersin.org/articles/10.3389/fnins.2015.00178 %V 9 %0 JOURNAL ARTICLE %@ 1662-453X %X Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the HPA axis, including effects on HPA axis associated genes/proteins, brain regions, and behaviors such as anxiety and depression. A better understanding of the mechanisms through which MA affects the HPA axis may lead to more effective treatment strategies for MA addiction.