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Front. Neurosci. | doi: 10.3389/fnins.2019.00869

Roles of neuropeptide Y in neurodegenerative and neuroimmune diseases

  • 1Department of Neurology, First Hospital of Jilin University, China
  • 2Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Sweden

Neuropeptide Y (NPY) is a neurotransmitter or neuromodulator that mainly exists in the nervous system. It plays a neuroprotective role in organisms and widely participates in the regulation of various physiological processes in vivo. Studies in both humans and animal models have been revealed that NPY levels are altered in some neurodegenerative and neuroimmune disorders. NPY plays various roles in these diseases, such as exerting a neuroprotective effect, increasing trophic support, decreasing excitotoxicity, regulating calcium homeostasis, and attenuating neuroinflammation. In this review, we will focus on the roles of NPY in the pathological mechanisms of neurodegenerative and neuroimmune diseases, highlighting NPY as a potential therapeutic target in these diseases.

Keywords: Neuropeptide Y, Neurodegenerative Diseases, Alzheimer’s disease, Parkinson’s disease, neuroimmune disorders, Guillain-Barré Syndrome

Received: 29 May 2019; Accepted: 02 Aug 2019.

Edited by:

Abel Santamaria, National Institute of Neurology and Neurosurgery (INNN), Mexico

Reviewed by:

ANAHI CHAVARRIA, National Autonomous University of Mexico, Mexico
Ana C. Jacobowski, Federal University of Mato Grosso do Sul, Brazil  

Copyright: © 2019 Li, Wu, Liu, Zhao, Zhu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Kangding Liu, Department of Neurology, First Hospital of Jilin University, Changchun, China,