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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.01102

Alterations of the gut microbiota in multiple system atrophy patients

 Linlin Wan1, Xin Zhou1, Chunrong Wang1,  Zhao Chen1, Huirong Peng1, Xuan Hou1, Yun Peng1, Puzhi Wang1, Tianjia Li1, Hongyu Yuan1, Yuting Shi1, Xiaocan Hou1,  Keqin Xu1, Yue Xie1, Lang He1, Kun Xia2,  Beisha Tang1 and  Hong Jiang1*
  • 1Xiangya Hospital, Central South University, China
  • 2Central South University, China

Multiple system atrophy (MSA) is a fatal neurodegenerative disease, and the pathogenesis is still quite challenging. Emerging evidence has shown that brain–gut–microbiota axis served a pivotal role in neurological diseases, however, researches utilizing metagenomic sequencing to analyze the alteration in gut microbiota of MSA patients were quite rare. Here, we carried out metagenomic sequencing in feces of 15 MSA patients and 15 healthy controls, to characterize the alterations in gut microbial composition and function of MSA patients in mainland China. The results showed that gut microbial community of MSA patients was significantly different from healthy controls, characterized by increased genus Akkermansia and species Roseburia hominis, Akkermansia muciniphila, Alistipes onderdonkii, Streptoococcus parasanguinis, Staphylococcus xylosus, while decreased genera Megamonas, Bifidobacterium, Blautia, Aggregatibacter and species Bacteroides coprocola, Megamonas funiformis, Bifidobacterium pseudocatenulatum, Clostridium nexile, Bacteroides plebeius, Granulicatella adiacens. Further, functional analysis based on KEGG database revealed aberrant functional pathways in fecal microbiome of MSA patients. In conclusion, our findings provided evidence for dysbiosis in gut microbiota of Chinese MSA cohorts, and helped develop new testable hypotheses on pathophysiology of MSA.

Keywords: Multiple System Atrophy, microbiota, Metagenomics, functional pathways, Inflammation

Received: 04 May 2019; Accepted: 30 Sep 2019.

Copyright: © 2019 Wan, Zhou, Wang, Chen, Peng, Hou, Peng, Wang, Li, Yuan, Shi, Hou, Xu, Xie, He, Xia, Tang and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Hong Jiang, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China, jianghong73868@126.com