In the original article, the Supplementary Table 4 and the Supplementary Figure 6, cited on page 6 in the original article, are missing from the Supplementary Materials. The corrected Supplementary Table 4 and Supplementary Figure 6 are shown below. The Supplementary Material of the original article has been updated.
Table S4
| Peptide | XIC Peak Areas x 105(mean±SD) and Frequency | ||||
|---|---|---|---|---|---|
| G1 (nr 19) | G2 (nr 8) | G3 (nr 8) | HC (nr 34) | ANOVA p value | |
| α-defensin 1 | 2.2 ± 2.3 (19) | 2.3 ± 1.8 (8) | 0.6 ± 0.8 (5) | 0.5 ± 0.6 (24) | p <0.0001 (G1vs G3*, G2 vs G3*, G1 vs HC***, G2 vs HC**) |
| α-defensin 2 | 1.5 ± 1.5 (19) | 1.5 ± 1.2 (7) | 0.4 ± 0.6 (5) | 0.4 ± 0.4 (27) | p = 0.0003 (G1vs G3*, G1 vs HC**, G2 vs HC*) |
| α-defensin 3 | 0.7 ± 0.5 (16) | 0.8 ± 0.5 (8) | 0.2 ± 0.4 (2) | 0.2 ± 0.3 (17) | p <0.0001 (G1vs G3*, G2 vs G3*, G1 vs HC***, G2 vs HC**) |
| α-defensin 4 | 0.2 ± 0.3 (8) | 0.4 ± 0.2 (8) | 0.04 ± 0.08 (2) | 0.05 ± 0.1 (11) | p = 0.0004 (G1vs G2*, G2 vs G3**, G2 vs HC***) |
| Tβ4 | 0.5 ± 0.6 (14) | 1.1 ± 0.9 (8) | 0.2 ± 0.4 (3) | 0.2 ± 0.4 (16) | p = 0.002 (G2vs G3**, G2 vs HC**) |
| Stath. 2P | 8.8 ± 7.7 (19) | 5.9 ± 4.4 (6) | 11.0 ± 7.1 (8) | 1.1 ± 0.9 (33) | p <0.0001 (G1 vs HC***, G2vs HC*, G3 vs HC***) |
| Stath. Des1-9 | 0.5 ± 0.6 (16) | 0.6 ± 0.9 (6) | 0.8 ± 0.6 (7) | 0.08 ± 0.1 (24) | p = 0.0002 (G1 vs HC**, G3 vs HC**) |
| P-C peptide | 9.3 ± 5.1 (19) | 8.6 ± 12.6 (6) | 12.3 ± 6.9 (8) | 5.6 ± 4.4 (34) | p = 0.01 (G3 vs HC*) |
| Cyst. B tot | 2.0 ± 2.2 (18) | 1.9 ± 1.6 (8) | 0.9 ± 1.2 (7) | 9.3 ± 5.1 (27) | p = 0.006 (G1vs HC*, G2 vs HC*) |
| Cyst A | 1.8 ± 1.6 (17) | 2.9 ± 1.9 (8) | 1.2 ± 0.9 (7) | 1.0 ± 0.9 (29) | p = 0.02 (G2 vs HC*) |
| S100A8 tot | 1.1 ± 1.5 (12) | 0.9 ± 1.1 (6) | 0.4 ± 0.5 (4) | 0.08 ± 0.2(5) | p <0.0001 (G1 vs HC***, G2 vs HC**) |
| S100A8-SNO | 1.1 ± 2.3 (9) | 0.7 ± 1.0 (3) | Not detected | Not detected | p <0.0001 (G1 vs G3*, G1 vs HC***) |
| S100A9(S) tot | 1.1 ± 1.5 (18) | 0.9 ± 1.1 (7) | 0.4 ± 0.5 (7) | 0. .5 ± 0.8 (16) | p <0.0001 (G1 vs HC***, G2 vs HC*) |
XIC peak areas values (mean ± SD) normalized on TPC, frequencies and p-values obtained by statistical analysis by comparing the three patients' groups treated with different therapies by non-parametric ANOVA with the Krustal-Wallis test and Dunn's post test. p-values > 0.05 are not statistically significant (∙).
Supplementary Figure 6
Total protein concentration measured in the subgroups of patients with different pharmacological treatment.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Summary
Keywords
Alzheimer disease, salivary proteomics, S100A, cystatins, α-defensins, thymosin β4, antimicrobial peptides, oxidative stress
Citation
Contini C, Olianas A, Serrao S, Deriu C, Iavarone F, Boroumand M, Bizzarro A, Lauria A, Faa G, Castagnola M, Messana I, Manconi B, Masullo C and Cabras T (2021) Corrigendum: Top-Down Proteomics of Human Saliva Highlights Anti-inflammatory, Antioxidant, and Antimicrobial Defense Responses in Alzheimer Disease. Front. Neurosci. 15:743596. doi: 10.3389/fnins.2021.743596
Received
18 July 2021
Accepted
22 July 2021
Published
13 August 2021
Volume
15 - 2021
Edited and reviewed by
Rossen Donev, MicroPharm Ltd, United Kingdom
Updates
Copyright
© 2021 Contini, Olianas, Serrao, Deriu, Iavarone, Boroumand, Bizzarro, Lauria, Faa, Castagnola, Messana, Manconi, Masullo and Cabras.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Barbara Manconi bmanconi@unica.it
This article was submitted to Neurogenomics, a section of the journal Frontiers in Neuroscience
†These authors have contributed equally to this work and share first authorship
‡These authors have contributed equally to this work and share last authorship
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.