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Review ARTICLE

Front. Oncol., 24 October 2016 | https://doi.org/10.3389/fonc.2016.00223

Advance Care Planning in Patients with Primary Malignant Brain Tumors: A Systematic Review

  • 1Department of Rehabilitation Medicine, Royal Melbourne Hospital (RMH), Melbourne, VIC, Australia
  • 2Department of Medicine (RMH), University of Melbourne, Melbourne, VIC, Australia
  • 3School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia

Advance care planning (ACP) is a process of reflection and communication of a person’s future health care preferences, and has been shown to improve end-of-life (EOL) care for patients. The aim of this systematic review is to present an evidence-based overview of ACP in patients with primary malignant brain tumors (pmBT). A comprehensive literature search was conducted using medical and health science electronic databases (PubMed, Cochrane, Embase, MEDLINE, ProQuest, Social Care Online, Scopus, and Web of Science) up to July 2016. Manual search of bibliographies of articles and gray literature search were also conducted. Two independent reviewers selected studies, extracted data, and assessed the methodologic quality of the studies using the Critical Appraisal Skills Program’s appraisal tools. All studies were included irrespective of the study design. A meta-analysis was not possible due to heterogeneity amongst included studies; therefore, a narrative analysis was performed for best evidence synthesis. Overall, 19 studies were included [1 randomized controlled trial (RCT), 17 cohort studies, 1 qualitative study] with 4686 participants. All studies scored “low to moderate” on the methodological quality assessment, implying high risk of bias. A single RCT evaluating a video decision support tool in facilitating ACP in pmBT patients showed a beneficial effect in promoting comfort care and gaining confidence in decision-making. However, the effect of the intervention on quality of life and care at the EOL were unclear. There was a low rate of use of ACP discussions at the EOL. Advance directive completion rates and place of death varied between different studies. Positive effects of ACP included lower hospital readmission rates, and intensive care unit utilization. None of the studies assessed mortality outcomes associated with ACP. In conclusion, this review found some beneficial effects of ACP in pmBT. The literature still remains limited in this area, with lack of intervention studies, making it difficult to identify superiority of ACP interventions in pmBT. More robust studies, with appropriate study design, outcome measures, and defined interventions are required to inform policy and practice.

Introduction

Primary brain tumors (BT) are a diverse group of neoplasms, affecting approximately 7 persons per 100,000 population annually worldwide (1). Primary BT predominantly are malignant gliomas, and half of these are glioblastoma multiforme (GBM) (1). The diagnosis of primary malignant brain tumor (pmBT) heralds a dramatic change in life expectancy for patients, with limited effective treatment options, progressive neurological deterioration, and high mortality rates. Despite advances in available therapies, GBM patients have a median survival of approximately 14 months only (2). Many pmBT patients experience ongoing difficulties related to the disease itself with high symptom burden (3, 4), and treatments used. They also experience other disabilities, such as fatigue, difficulties with mobility and self-care, cognitive and intellectual decline, behavioral dysfunction, personality changes, and psychological problems, such as depression and anxiety. There are significant implications of these disabilities on caregivers with role reversal within families, vocational issues, financial strain, and reduced quality of life (QoL) (5, 6).

The neuropalliative supportive care needs of pmBT patients had previously been recognized and national guidelines acknowledged ongoing considerable gaps in provision of end-of-life (EOL) care, including earlier Advance Care Planning (ACP) discussions for those with terminal conditions (79). ACP is the ongoing process that involves decisions made by patients, in consultation with surrogate decision-makers, family and health care providers regarding their values, beliefs, life-sustaining treatment preferences, goals of care (GOC), and palliative care options, should they later become incapable of expressing such wishes. ACP may further include the patient completing an advance directive (AD) which documents his or her wishes and/or appointment of a substitute decision-maker.

Advance care planning is recognized as an important element in improving EOL care, and one that is increasingly used in an international context because it allows patients to direct their own ongoing care. This contributes to shared decision-making, resulting in enhanced QoL for the patient. ACP has also been shown to increase patient and family satisfaction with EOL care (10, 11) and improve understanding and compliance between physicians and family members with patients’ wishes for EOL care (10, 12). In addition, ACP increases the likelihood of a person dying in his or her preferred place (13), increases hospice use, and reduces hospitalization, with lower stress levels, anxiety, and depression in surviving relatives (10, 11).

Discussing EOL issues with pmBT patients is especially challenging. The rapidity of cognitive decline due to tumor growth, tumor-related seizures or treatment effects (14) often precludes the expression of future wishes and treatment preferences, leaving families and clinicians to decide whether and when to withdraw interventions after patients have lost capacity to decide for themselves. Furthermore, delirium, dysarthria, dysphasia, and personality changes are also common (3, 8), which may lead to impaired communication about complex topics, such as hydration, nutrition, steroid interruption, and palliative sedation (3). Many often have limited understanding of their treatment options, and prognostic uncertainty impacting on this process, resulting in difficulty achieving realistic expectations and determining appropriate treatment decisions (15). Cultural, religious and spiritual factors also tend to play a role in EOL decision-making. Many clinicians often avoid the topic in practice due to time pressures, lack sufficient communication skills training, and are uncertain about timing and content of ACP with fear of upsetting patients (16).

Advance care planning has been widely explored in the literature in different patient cohorts, including cancer, chronic renal failure, heart failure, chronic obstructive pulmonary disease, and other life-limiting conditions. A number of studies had previously investigated ACP in the BT cohort (17, 18). The body of research in this area is growing; however, published studies vary in methodology, scope, and interventions with different findings and conclusions. The outcomes following ACP interventions need to be established. However, to date, there is no systematic review evaluating ACP in pmBT patients to guide clinicians in ACP implementation. Therefore, the aim of this study is to systematically evaluate the current evidence and efficacy of ACP in pmBT patients to assist treating clinicians, and to ensure that services and supports are directed appropriately in this population.

Methods

An integrated approach was employed, which included a comprehensive review of literature (peer review and gray literature), using medical and health science electronic databases (PubMed, Cochrane, Embase, MEDLINE, ProQuest, Social Care Online, Scopus, and Web of Science) up to July 2016. Bibliography search of identified articles and manual search of relevant journals for additional references were conducted. A further gray literature search was conducted using different internet search engines and websites, such as the PQDT Open, OATD, and Google Scholar. In addition, various healthcare institutions; and governmental and non-governmental organizations associated with management of individuals with pmBT were also explored for relevant studies. Authors and known experts in the field were contacted.

The search strategy used Medical Subject Headings (MeSH) or equivalent key words relating to pmBT and ACP. Premutations of the following search terms were truncated and exploded: brain cancer, neoplasm or malignancy, ACP, ADs, EOL communication, life-sustaining treatment preferences, EOL decision-making, EOL care, and living will. All unpublished studies and all trials registered in relevant registries were scrutinized to reduce publication bias.

Inclusion and Exclusion Criteria

A protocol for searching was established prior to commencement of the search. ACP was defined as “any advance discussions or directives pertaining to patients’ life-sustaining treatment preferences, goals of care, palliative care options, appointment of a health care proxy and may further include the completion of an AD” (19). Inclusion criteria were determined as follows: (1) articles published in peer-reviewed journals, irrespective of study design; (2) studies with participants with confirmed diagnosis of pmBT [also specified as malignant glioma, high-grade glioma (HGG), anaplastic astrocytoma, GBM, anaplastic oligodendroglioma, oligoastrocytoma or World Health Organization (WHO) tumor grades III and IV]; and (3) 18 years and above. Other studies conducted in different patient cohorts were also included if they provided data for >50% of pmBT patients.

Articles were excluded if the participant subgroups with pmBT were not clearly defined. Theses, narrative reviews, editorials, case reports/series, and published conference abstracts were also excluded.

Study Selection and Data Extraction

Two authors (Krystal Song and Fary Khan) independently screened all identified study titles and abstracts for inclusion based on the selection criteria. Any disagreements were resolved by consensus discussion with the third author (Bhasker Amatya). Preliminary synthesis was conducted by using a standard pro forma created a priori with data extraction from studies, which included study characteristics (publication year and country, study type, sample characteristics, methodology, outcome measures, key findings) and intervention characteristics where feasible [type, intensity, domain, setting, delivery mode, duration and any information available about training and feasibility (e.g., adherence)]. Additional description of interventions was obtained from the study corresponding author where necessary.

Thematic analysis of the primary findings presented by each study was undertaken. Findings were individually scrutinized by the two authors (Krystal Song and Fary Khan), who discussed, extracted, and refined key emergent themes. Final themes were then developed and reviewed with feedback sought from the third author (Bhasker Amatya). Any disagreements were resolved by group discussions.

Two authors (Krystal Song and Bhasker Amatya) independently assessed the methodologic quality and grade of evidence of included studies with the CASP tool (20). The CASP tool uses a systematic approach to appraise different study designs from the following domains: study validity, methodologic quality, presentation of results, and external validity (20). The articles were graded independently, and any disagreements were resolved through consensus. Each of the items from the checklists were judged with “yes” (low risk of bias, score 1), “no” (high risk of bias), or “cannot tell” (unclear or unknown risk of bias, score 0). Total scores were used to grade the methodologic quality of each study assessed [maximum score 11 for randomized controlled trial (RCTs); 12 for cohort studies; 10 for qualitative studies] (20).

Results

Results of the Search

The combined searches retrieved a total of 2177 published titles and abstracts, of which 1838 were screened after removal of duplicates. Seventeen articles met inclusion criteria for analysis. Further citation and journal hand searches identified two articles that were included for final analysis. In total, 19 articles (1 RCT, 17 cohort studies, 1 qualitative study) were determined as eligible for this systematic review. See Figure 1 for a PRISMA flow diagram of the study selection process.

FIGURE 1
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Figure 1. Flow chart of review selection process. ^ACP, advance care planning; *pmBT, primary malignant brain tumor; **RCT, randomized controlled trial.

Study Characteristics

The included studies were conducted in different countries: three each were conducted in the USA, Italy, and Australia; two each in Germany, Austria, Netherlands, and UK, while two studies were multicentered and conducted in three different countries: The Netherlands, Austria, and UK. The included studies evaluated a total of with 4686 participants. Detailed information regarding the included studies is presented in Table 1. Only one randomized controlled trial (RCT) was identified which evaluated a video decision support tool on ACP in pmBT patients (17). Other were observational studies, including 14 retrospective and 3 prospective cohort studies and 1 was a qualitative study.

TABLE 1
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Table 1. Summary of included studies.

Study Quality Assessment

There was consensus agreement amongst reviewers regarding methodology used in the studies. Table 2 provides a quality assessment of included studies using the CASP tool (20).The methodologic quality of included studies varied. The only included RCT was of moderate quality (CASP = 8/11). This study was, however, underpowered and had insufficient blinding procedures (17). The CASP scores for the 17 cohort studies ranged from 2 to 7 out of 12. The overall quality of most included cohort studies was assessed as low to moderate, of which eight studies were of moderate quality (3, 21, 22, 25, 28, 30, 32, 33). All cohort studies had substantial flaws in methodologic design with a high risk of bias related to heterogeneous patient characteristics, study design, and outcome analysis. Outcome measurement tools varied among studies, and some tools used were not validated.

TABLE 2
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Table 2. Levels of quality of individual studies (CASP approacha).

Synthesis of Results

Pooling of data was not possible due to heterogeneity among the included studies in terms of study design, interventions used and presentation of findings. Therefore, study findings are described narratively in most relevant subheadings.

Description of ACP Interventions

In a RCT, El-Jawahri et al. evaluated the feasibility and effectiveness of a video GOC decision support tool in facilitating ACP in pmBT patients (17). This video tool was used to supplement a verbal description in aiming to improve EOL decision-making in pmBT patients. Fifty participants were randomly assigned to either the verbal narrative (n = 27) or additional video tool after the verbal narrative (n = 23). The findings suggested that the video tool was effective in promoting comfort care and gaining confidence in decision-making compared to verbal description only. No participants in the video tool group preferred life-prolonging care, 4.4% preferred basic care, 91.3% preferred comfort care, and only 4.4% were uncertain (p < 0.0001), while in participants in the verbal narrative group, 25.9% of participants preferred life-prolonging care, 51.9% basic care, and 22.2% comfort care (17). However, the effect of the video intervention on QoL and care at the EOL were unclear. This study was underpowered with small sample size and has methodological flaws such as lack of blinding of assessors (17).

Another intervention study assessed the impact of a pilot program of comprehensive palliative care (including the provision of palliative ACP) for pmBT patients on place of death (POD), rehospitalization rate in the last months of life, and the cost-effectiveness of the care model (30). Of the 529 patients who died, 61% were assisted at home until the EOL, 22.2% died in hospital, and 16.8% died in inpatient hospice. Hospitalization readmission rates and intensive care unit utilization in the last 2 months of life in a subgroup of GBM patients assisted by the home care program were significantly lower than the control group who did not receive home assistance (16.7 vs. 38%, respectively; p < 0.001) (30). The authors, however, failed to report the impact of palliative home care program on QoL, quality of dying or caregiver burden.

Prevalence and Preference for Timing and Content of EOL Discussions

End-of-life discussions were poorly used in the included studies. Two studies reported that approximately 12–40% of pmBT patients did not have EOL discussions involving decisions regarding treatment preferences, health care proxy (HCP), palliative care consultation, hospice discussion, and resuscitation wishes (18, 25).

Gofton et al. retrospectively evaluated timing and content of EOL discussions in pmBT patients who were admitted to hospital within 6 months of death (25). The authors found that of 43 deceased pmBT patients, potential admission to a hospice was discussed in 38 patients (88%), a HCP was appointed in 33 patients (77%) and 28 patients (65%) had a do-not-resuscitate (DNR) order. Hospice discussions were initiated at a median of 39 days before death, and DNR orders were filled in at a median of 41 days before death. There was a wide degree of variation in the timing of EOL discussions such as hospice planning (1–140 days) prior to death and resuscitation wishes (1–140 days) (25). Overall, discussions about treatment restrictions in pmBT patients were often initiated relatively close to death (25). Common EOL treatment decisions also concern hydration (87%), comfort care (82%), steroid interruption (45%) tube feeding (13%), palliative sedation (13%), and ADs (6%) (30).

AD Completion Rates and Nomination of Health Care Proxy

Rates of AD completion varied widely between countries. In a study examining EOL care in HGG patients conducted in three European countries, the authors reported significant contrast in written AD completion, including 46% in Dutch, 37% in British, and only 6% in Austrian patients (p < 0.001) (28). Overall, the findings from the included studies in this review showed that around 0–76% of pmBT patients had an AD completed (3, 5, 17, 18, 23, 26, 28, 30, 31, 34). The nomination of health care proxies ranged from 8 to 77% among the studies (3, 22, 26).

Use of Palliative Care and Hospice, and Place of Death

The use of palliative care in pmBT is widely discussed in the included studies (3, 21, 24, 25, 27, 30, 31, 33). Collins et al. examined the clinical presentation and patterns of care for short-term pmBT survivors (21). The authors found that 22% of short-term survivors (those who died during initial admission) did not have contact with palliative care. Of the 23% (n = 264) of patients who survived the diagnosis admission but died within 120 days later, only 12% had a palliative care consultation for appropriate planning and support during their diagnosis admission. Surprisingly, the majority (38%) died in a palliative care bed/inpatient hospice, 32% died at home, and 30% in an acute hospital (21). It was suggested that timely referral to palliative care at the initial point of discharge may have facilitated death at home or in a more appropriate and cost-efficient hospital setting. This study was of retrospective design and did not evaluate other factors predicting shorter survival rates. In another study, Heese et al. retrospectively assessed the palliative care involvement in EOL support of pmBT patients and found that only 21.3% of patients received care from physicians who specialized in palliative medicine in their final 4 weeks prior to death (27).

A study conducted in Australia found that pmBT patients who received any palliative care in the last 120 days before death were more likely to die out of hospital (25). Pace et al. evaluating a pilot program of comprehensive palliative neurological home care for BT patients (30), showed a subgroup of GBM patients (n = 425) who were assisted by the palliative home care program had significantly lower hospital readmission rates, ICU utilization in the last 2 months of life compared to the control group who did not receive home assistance (16.7% vs. 38% respectively; p < 0.001) (30).

Similarly, there was variability in the reported POD among different countries. Study findings suggested that the reported rate of dying at home were 21–82% in USA (22, 25), 26–32% in Australia (21, 33), 40–66% in The Netherlands (5, 18, 28, 29, 31, 32), 53–65% in Italy (3, 30, 31), 16–33% in UK (6, 24), and approximately 23–48% in Germany (26, 27). Overall, approximately 8–33% of pmBT patients were reported dying in inpatient hospice (5, 21, 2731, 33) or with affiliated hospice support (22, 25).

Patient/Surrogate Confidence and Congruence in EOL Decision-Making

Patient confidence in ACP decision-making was shown to be associated with various factors. El-Jawahri et al. in a RCT showed that patient confidence in EOL decision-making and ACP increased when a video support decision-making tool was used (17). The mean uncertainty score regarding decision-making (range, 3–15; higher score indicating less uncertainty) was significantly higher in the intervention group (with additional video support) compared to controls with verbal support only (13.7 vs. 11.5; p < 0.002) (17), with video arm participants significantly preferring comfort care (p < 0.0001). Approximately 82.6% in the video intervention arm in this study reported being very comfortable watching the video (17).

Sizoo et al. retrospectively assessed the patients’ relatives concerning EOL phase of pmBT patients involving health-related QOL, decision-making, place and quality of EOL care and dying with dignity (32). The authors found that higher satisfaction rates with the physician, fewer transitions between health-care settings in the EOL phase, ability to communicate EOL decisions, and more frequently dying at preferred POD were associated with a dignified death (32). This study, however, had various methodological flaws including retrospective design, proxy ratings with recall bias, and small sample size.

Various studies used congruence with patient wishes as an outcome measure. The findings suggested that completion of an AD is not often sufficient to ensure congruence with patients’ wishes for EOL care. In a study examining EOL care in pmBT patients in three European countries, physicians made decisions that were not in accordance with patients’ earlier expressed preferences, was reported in 10% of patients (28). The authors also found that the actual POD was in accordance with preferred POD only in 67% of Dutch, 56% of the Austrian and 39% of the British patients (p = 0.014), likely reflecting health care system differences toward EOL care (28).

Another retrospective survey of physicians in the Netherlands examining the EOL preferences of patients and congruence with physician decisions showed that in 40% of pmBT patients, physicians were unaware of patients’ EOL preferences, even though several had an AD according to their relatives (18). The authors found that these preferences were related to life-prolonging treatment preferences, admission to hospital, palliative sedation or euthanasia. The authors also indicated that there was incongruence between physician and patients’ EOL wishes with decisions made against patient’s wishes in a small proportion of patients (18).

Patient–Clinician Communication and Interaction Quality, Patient and Family Well-Being, QoL, and Satisfaction

Four studies found a significant beneficial effect of ACP on patient-clinician communication and interaction quality (28, 3032). Sizoo et al. assessed the proportion of pmBT patients dying with dignity as perceived by their relatives (32). Factors most predictive of a dignified death included higher satisfaction rates with the physician, the ability to communicate EOL decisions and the absence of transitions between healthcare settings (32). These findings were consistent with another cross-national study comparing EOL care in pmBT patients in three European countries (28). Good quality of care (QOC) during the last 3 months prior to deaths was shown to be associated with effective treatment of physical symptoms and satisfaction with information provided (28). A home neuro-oncological palliative care program also had a positive impact on perception of QOC through communication and psychological support offering ACP and EOL care discussions perceived by caregivers (30, 31).

The review identified a limited number of studies examining the outcomes of ACP on patient or family well-being, QoL, and satisfaction. Caregiver QOL was generally rated low in the context of pmBT patients’ illness trajectory and this did not differ between caregivers of patients, who died at home (40%) or in hospital (46%) (5). One study examining the EOL phase of pmBT patients found that with those patients who died with dignity, EOL decisions were more often explicitly discussed and relatives were more satisfied with physician(s) providing EOL care (32). The authors report that pmBT patients who died most often with dignity were those who died at home (83%), compared to those who died in other health care settings including hospice (71%), hospital (63%), and nursing home (50%) (32). This study had some limitations due to retrospective design, recall bias based on relatives’ information and small sample size.

Hospital Utilization and Mortality Rates

Hospital utilization is frequently measured as an economic marker of health care costs. Hospital utilization in pmBT patients, in terms of POD, reported among the studies varied between different countries and ranged from 7 to 46% (5, 6, 18, 21, 2633).

Two studies assessed hospital utilization as an outcome measure (21, 30). Collins et al. examined the patterns of care for shorter term survivors of pmBT patients in Australia (21). The authors divided these patients into Group 1 (19%, n = 218) (died during diagnosis admission), Group 2 (23%, n = 264) (survived diagnosis admission but died within 120 days from diagnosis) and Group 3 (58%, n = 678) (died thereafter) (21). As expected, Group 1 who had higher severity of illness burden and older patients tend to have higher hospital utilization. Group 1 comprised a greater proportion of patients aged over 75 years (p = 0.015), more patients with multifocal tumor (p = 0.001), and with more comorbidities (p = 0.001). These patients (Group 1) have higher total bed days per patient (p < 0.001), greater emergency department use (p = 0.001), greater ICU use (p = 0.001) and lower rates of resection (p < 0.001) (21). Another study demonstrated that in a subgroup of GBM patients, a home care neuro-oncological program, which included palliative ACP, significantly reduced hospital readmissions rates and ICU utilization in last 2 months of life compared to their counterparts without this service (16.7 vs. 38%, respectively; p < 0.001) (30). Furthermore, there was a significant difference in cost for the care delivered during hospital stays ($9990 vs. $76,000; p < 0.001) (30).

None of the studies assessed mortality outcomes associated with ACP, for example, whether or not ACP was associated with a difference in mortality rates in pmBT patients.

Discussion

This systematic review provides an evidence-based overview of ACP in pmBT patients, assimilating published literature for currently available evidence by including both quantitative and qualitative studies. The review highlights the lack of robust, methodologically strong studies evaluating ACP in this population, with very few ACP interventions trialed to date. Due to the heterogeneity of the studies, best evidence synthesis was performed using a narrative approach. Only one RCT was found, which showed a positive effect in enhancing ACP information delivery to pmBT patients (17). The majority of the included studies in this review were retrospective in design, making it difficult to assess cause and effect of ACP interventions, and how to effectively conduct ACP in this population. These studies focused on EOL issues in pmBT patients, patterns of care, decision-making and palliative care support. The use of ACP also varied amongst countries with the lack of consistency of use and not being constant across the various contexts of care. Despite these limitations, the findings suggest some beneficial effects of ACP in pmBT, which include dignified death, lower hospital utilization and higher carer satisfaction.

This review highlights various issues in this area. First, there were limited number of studies examining ACP discussions in pmBT patients (18, 25) and, hence, it is difficult to draw conclusions on the existing rates of EOL discussions involving various aspects of ACP in pmBT patients. The findings also suggest that pmBT patients’ awareness of their prognosis varies considerably, with 40% being unaware of it (3, 35). The rates of AD completion ranged largely from none to 76% of patients, varying between different countries (35, 18). Although the presence of an AD is aimed at improving EOL care by involving an understanding between physicians and family members with regards to patients’ wishes and patients dying more often at preferred POD with less caregiver burden (10), AD completion was not always found effective. Congruence with patient wishes and EOL discussions was an interesting outcome measure noted in this review. In Europe, 10% of patients earlier expressed preferences were not in accordance with physicians’ decisions (28). Another study also reported that in 40% of patients, physicians were unaware of patients’ AD (18). There are many factors that impact on the inefficiency of these ACP discussions, and processes are often ineffective due to poor patient–physician communication and patients’ lack of sufficient medical knowledge to engage in these discussions. Furthermore, health professionals may differ in the interpretation of the patient’s current preference and may not always be reflected in their previous AD. Regular evaluation of documented AD is, therefore, advisable (36), along with clear communication with patients and surrogate decision-makers during ACP discussions regarding future wishes and treatment preferences. These goals should be reviewed over time as they may change depending on illness trajectory (18).

Second, there is limited data to demonstrate the appropriate timing of EOL discussions in patients with pmBT. The findings suggest a wide degree of variation in the timing of EOL discussions in pmBT patients such as hospice planning prior to death and resuscitation wishes (25). One study stated that 52% of patients were incompetent to assess their own situation in the last weeks of life due to cognitive disturbances, aphasia and/or delirium (25), with another 33% of patients who had lost their competence during the last week of life due to reduced consciousness (25). With a high chance of progressive functional and cognitive decline in pmBT patients and given the importance placed on mental competence in determining their QoL (18), timely and early discussions regarding GOC and treatment in EOL phase including ACP are encouraged (9, 18, 25). This will allow increased patient autonomy and patients to have an active shared treatment decision-making process with their physicians and family, resulting in higher QoL, increased survival rates and less caregiver distress (10). Authors suggest that the most frequent EOL decisions within the last 4 weeks of life in pmBT patients tend to focus upon hydration, nutrition, steroid interruption, AD, and palliative sedation (3).

Third, the effect of ACP in pmBT patients and their caregivers on confidence, well-being, QoL, and satisfaction were surprisingly not avidly evaluated. On study reported that an additional intervention including an ACP video had a positive impact on patients in preferring comfort care and avoiding CPR, with improved EOL decision-making (17). Studies evaluating caregivers and family perspectives found mixed results. One study found that although patient and caregivers had expressed their preferences for POD, the majority (68%) were not able to fulfill their preferences (5). For patients who died a dignified death, EOL decisions were more often explicitly discussed. Furthermore, caregivers were more satisfied with physician(s) providing EOL care (32), as they perceived that their loved one died a dignified death.

Place of death has also been commonly evaluated. Consistent with other cancer populations, most terminally ill pmBT patients prefer to be at home during the EOL phase (37, 38). However, the preferred POD may change over time and the actual POD may not be in line with patient’s preferences. There is a wide variability in POD between different countries, likely reflecting differences in feasibility of home care, use of hospices, different health models of care, and access to healthcare services, such as palliative care support.

Primary malignant brain tumor patients have diverse and fluctuating symptoms, and their needs differ from other palliative patients. Management of these complex patients should ideally performed by practitioners with expertise in supportive care of terminal neurological conditions. A neuropalliative model is an important example of a comprehensive approach to ACP delivery, seeking to improve QoL of patients and their families, as well as to address physical, psychosocial and spiritual needs (39, 40). The ultimate aim is to provide better care to those who need it most at the appropriate time, and to facilitate ACP discussions. The timeliness of referral to palliative care continues to be of great interest to healthcare professionals involved in the care of pmBT patients, however, the service remains under-utilized or continues to be initiated sporadically (21, 24, 25), and often used late in the cancer trajectory. To date, only a limited number of studies have evaluated early palliative care in conjunction with standard therapies for pmBT patients (41). This systematic review found only one moderate quality study that adopted a comprehensive approach to ACP delivery, including a pilot program of comprehensive palliative home care for pmBT patients (30). Consistent with the neuropalliative care framework, this model focused on patient’s needs for care in all stages of disease, aiming to support the families, deliver ACP information, and was shown to reduce economic costs for care delivered, and rehospitalization rates (30).There were no other studies which directly examined the cost-effectiveness for treatments involving ACP and mortality outcomes in this population.

There are several limitations in methodology and completeness of the retrieved literature. Despite the comprehensive search using extended range of terms to capture the relevant literature, the search strategy principally encompassed only cited literature. Furthermore, the only reference lists within the relevant articles was searched for other possible articles missed in electronic searches, this may have introduced a reference bias and may have missed some relevant articles, including unpublished trials. Finally, though the CASP approach used to appraise studies is a robust system for evaluating various trial-based evidence, its sensitivity is still debatable (42). As studies identified in this review were of mixed methods, CASP was appropriate tool. As aforementioned, pooling data for meta-analyses to make meaningful statements was not possible. The generalizability of the results is limited, due to heterogeneity in study designs, study settings, interventions used, participant recruitment processes, and outcomes measures used. Furthermore, generalizability of results to different countries and healthcare systems is limited as studies were conducted predominantly in USA and Europe, with varied healthcare systems.

In conclusion, this systematic review highlights sparse literature and lack of high-quality studies examining ACP in pmBT patients. Assimilation of data from existing studies was difficult due to heterogeneity amongst studies and their findings. The gap in current research should not be interpreted as ineffectiveness of ACP in this population, as ACP is important for pmBT patients where the risk of cognitive impairment and losing decision-making capacity are high. Overall, this review highlights the increasing awareness of ACP in pmBT patients for effective management in illness trajectory, particularly in terminal phase. ACP is an important element in improving EOL care of pmBT patients and needs to be considered for improved and/or shared decision-making by patients and family, increased patient and family satisfaction, improved physician and patient relationship, and enhanced QOL of the patient. Further high quality studies, especially RCTs, are needed to ascertain most effective types of ACP interventions in HGG population, and outcome measures could also be potentially standardized after evaluation in consensus meetings to overcome heterogeneity of study outcome measures.

Author Contributions

KS, FK, CV, and BA participated in discussions to conceive the study. KS and BA participated in the analysis of results. KS participated in writing the manuscript, and all authors read and approved the final manuscript.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Abbreviations

ACP, advance care planning; AD, advance directive; BT, brain tumors; CASP, Critical Appraisal Skills Program; EOL, end-of-life; GBM, glioblastoma multiforme; pmBT, primary malignant brain tumor; QOC, quality of care; QoL, quality of life; WHO, World Health Organization.

References

1. Flowers A. Brain tumors in the older person. Cancer Control (2000) 7(6):523–38.

PubMed Abstract | Google Scholar

2. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med (2005) 352:987–96. doi:10.1056/NEJMoa043330

PubMed Abstract | CrossRef Full Text | Google Scholar

3. Pace A, Di Lorenzo C, Guariglia L, Jandolo B, Carapella CM, Pompili A. End of life issues in brain tumor patients. J Neurooncol (2009) 91:39–43. doi:10.1007/s11060-008-9670-x

PubMed Abstract | CrossRef Full Text | Google Scholar

4. Sizoo EM, Braam L, Postma TJ, Pasman HR, Heimans JJ, Klein M, et al. Symptoms and problems in the end-of-life phase of high-grade glioma patients. Neuro Oncol (2010) 12:1162–6. doi:10.1093/neuonc/nop045

PubMed Abstract | CrossRef Full Text | Google Scholar

5. Flechl B, Ackerl M, Sax C, Oberndorfer S, Calabek B, Sizoo E, et al. The caregivers’ perspective on the end-of-life phase of glioblastoma patients. J Neurooncol (2013) 112:403–11. doi:10.1007/s11060-013-1069-7

CrossRef Full Text | Google Scholar

6. Arber A, Faithfull S, Plaskota M, Lucas C, de Vries K. A study of patients with a primary malignant brain tumour and their carers: symptoms and access to services. Int J Palliat Nurs (2010) 16:24–30. doi:10.12968/ijpn.2010.16.1.46180

PubMed Abstract | CrossRef Full Text | Google Scholar

7. A National Framework for Advance Care Directives. The Clinical, Technical and Ethical Principal Committee of the Australian Health Ministers’ Advisory Council. (2011). Available from: http://www.coaghealthcouncil.gov.au/Portals/0/A%20National%20Framework%20for%20Advance%20Care%20Directives_September%202011.pdf

Google Scholar

8. Sizoo EM, Pasman HR, Dirven L, Marosi C, Grisold W, Stockhammer G, et al. The end-of-life phase of high-grade glioma patients: a systematic review. Support Care Cancer (2014) 22:847–57. doi:10.1007/s00520-013-2088-9

PubMed Abstract | CrossRef Full Text | Google Scholar

9. Walbert T, Khan M. End-of-life symptoms and care in patients with primary malignant brain tumors: a systematic literature review. J Neurooncol (2014) 117(2):217–24. doi:10.1007/s11060-014-1393-6

PubMed Abstract | CrossRef Full Text | Google Scholar

10. Detering KM, Hancock AD, Reade MC, Silvester W. The impact of advance care planning on end of life care in elderly patients: randomized controlled trial. BMJ (2010) 2010(350):c1345. doi:10.1136/bmj.c1345

CrossRef Full Text | Google Scholar

11. Molloy DW, Guyatt GH, Russo R, Goeree R, O’Brien BJ, Bédard M, et al. Systematic implementation of an advance directive program in nursing homes: a randomized controlled trial. JAMA (2000) 283(11):1437–44. doi:10.1001/jama.283.11.1437

PubMed Abstract | CrossRef Full Text | Google Scholar

12. Silveria MJ, Kim SY, Langa KM. Advance directives and outcomes of surrogate decision making before death. N Engl J Med (2010) 362(13):1211–8. doi:10.1056/NEJMsa0907901

PubMed Abstract | CrossRef Full Text | Google Scholar

13. Teno JM, Gruneir A, Schwartz Z, Nanda A, Wetle T. Association between advance directives and quality of end-of-life care: a national study. J Am Geriatr Soc (2007) 55(2):189–94. doi:10.1111/j.1532-5415.2007.01045.x

PubMed Abstract | CrossRef Full Text | Google Scholar

14. Talacchi A, Santini B, Savazzi S, Gerosa M. Cognitive effects of tumour and surgical treatment in glioma patients. J Neurooncol (2011) 103(3):541–9. doi:10.1007/s11060-010-0417-0

PubMed Abstract | CrossRef Full Text | Google Scholar

15. Halkett GK, Lobb EA, Oldham L, Nowak AK. The information and support needs of patients diagnosed with high grade glioma. Patient Educ Couns (2010) 79(1):112–9. doi:10.1016/j.pec.2009.08.013

PubMed Abstract | CrossRef Full Text | Google Scholar

16. Scott IA, Mitchell GK, Reymond EJ, Daly MP. Difficult but necessary conversations – the case for advance care planning. Med J Aust (2013) 199(10):662–6. doi:10.5694/mja13.10158

CrossRef Full Text | Google Scholar

17. El-Jawahri A, Podgurski LM, Eichler AF, Plotkin SR, Temel JS, Mitchell SL, et al. Use of video to facilitate end-of-life discussions with patients with cancer: a randomized controlled trial. J Clin Oncol (2010) 28:305–10. doi:10.1200/JCO.2009.24.7502

PubMed Abstract | CrossRef Full Text | Google Scholar

18. Sizoo EM, Pasman HR, Buttolo J, Heimans JJ, Klein M, Deliens L, et al. Decision-making in the end-of-life phase of high grade glioma patients. Eur J Cancer (2012) 48:226–32. doi:10.1016/j.ejca.2011.11.010

CrossRef Full Text | Google Scholar

19. Patel K, Janssen DJ, Curtis JR. Advance care planning in COPD. Respirology (2012) 17:72–8. doi:10.1111/j.1440-1843.2011.02087.x

CrossRef Full Text | Google Scholar

20. Critical Appraisal Skills Programme. CASP Checklists. (2016). Available from: http://www.casp-uk.net/#!casp-tools-checklists/c18f8

Google Scholar

21. Collins A, Sundararajan V, Brand CA, Moore G, Lethborg C, Gold M, et al. Clinical presentation and patterns of care for short-term survivors of malignant glioma. J Neurooncol (2014) 119:333–41. doi:10.1007/s11060-014-1483-5

PubMed Abstract | CrossRef Full Text | Google Scholar

22. Diamond EL, Russell D, Kryza-Lacombe M, Bowles KH, Applebaum AJ, Dennis J, et al. Rates and risks for late referral to hospice in patients with primary malignant brain tumours. Neuro Oncol (2016) 18(1):28–86. doi:10.1093/neuonc/nov156

CrossRef Full Text | Google Scholar

23. Song K. Advance care planning in patients with brain tumours: a prospective cohort study. J Cancer Res Ther (2015) 7(3):85–91. doi:10.14312/2052-4994.2015-12

CrossRef Full Text | Google Scholar

24. Faithfull S, Cook K, Lucas C. Palliative care of patients with a primary malignant brain tumour: case review of service use and support provided. Palliat Med (2005) 19:545–50. doi:10.1191/0269216305pm1068oa

PubMed Abstract | CrossRef Full Text | Google Scholar

25. Gofton TE, Graber J, Carver A. Identifying the palliative care needs of patients living with cerebral tumors and metastases: a retrospective analysis. J Neurooncol (2012) 108:527–34. doi:10.1007/s11060-012-0855-y

PubMed Abstract | CrossRef Full Text | Google Scholar

26. Golla H, Ale Ahmad M, Galushko M, Hampl J, Maarouf M, Schroeter M, et al. Glioblastoma multiforme from diagnosis to death: a prospective, hospital-based, cohort, pilot feasibility study of patient reported symptoms and needs. Support Care Cancer (2014) 22:3341–52. doi:10.1007/s00520-014-2384-z

PubMed Abstract | CrossRef Full Text | Google Scholar

27. Heese O, Vogeler E, Martens T, Schnell O, Tonn JC, Simon M, et al. End-of-life caregivers’ perception of medical and psychological support during the final weeks of glioma patients: a questionnaire-based survey. Neuro Oncol (2013) 15(9):1251–6. doi:10.1093/neuonc/not089

CrossRef Full Text | Google Scholar

28. Koekkoek JA, Dirven L, Reijneveld JC, Sizoo EM, Pasman HR, Postma TJ, et al. End of life care in high-grade glioma patients in three European countries: a comparative study. J Neurooncol (2014) 120:303–10. doi:10.1007/s11060-014-1548-5

PubMed Abstract | CrossRef Full Text | Google Scholar

29. Koekkoek JA, Dirven L, Sizoo EM, Pasman HR, Heimans JJ, Postma TJ, et al. Symptoms and medication management in the end of life phase of high-grade glioma patients. J Neuroncol (2014) 120:589–95. doi:10.1007/s11060-014-1591-2

PubMed Abstract | CrossRef Full Text | Google Scholar

30. Pace A, Villani V, Di Pasquale A, Benincasa D, Guariglia L, Ieraci S, et al. Home care for brain tumour patients. Neuro Oncol Pract (2014) 1(1):8–12. doi:10.1093/nop/npt003

CrossRef Full Text | Google Scholar

31. Pompili A, Telera S, Villani V, Pace A. Home palliative care and end of life issues in glioblastoma multiforme: results and comments from a homogeneous cohort of patients. Neurosurg Focus (2014) 37(6):E5. doi:10.3171/2014.9.FOCUS14493

PubMed Abstract | CrossRef Full Text | Google Scholar

32. Sizoo EM, Taphoorn MJ, Uitdehaag B, Heimans JJ, Deliens L, Reijneveld JC, et al. The end-of-life phase of high-grade glioma patients: dying with dignity? Oncologist (2013) 18:198–203. doi:10.1634/theoncologist.2012-0247

PubMed Abstract | CrossRef Full Text | Google Scholar

33. Sundararajan V, Bohensky MA, Moore G, Brand CA, Lethborg C, Gold M, et al. Mapping the patterns of care, the receipt of palliative care and the site of death for patients with malignant glioma. J Neurooncol (2014) 116:119–26. doi:10.1007/s11060-013-1263-7

PubMed Abstract | CrossRef Full Text | Google Scholar

34. Thier K, Calabek B, Tinchon A, Grisold W, Oberndorfer S. The last 10 days of patients with glioblastoma: assessment of clinical signs and symptoms as well as treatment. Am J Hosp Palliat Care (2015) 1–4. doi:10.1177/1049909115609295

PubMed Abstract | CrossRef Full Text | Google Scholar

35. Davies E, Higginson IJ. Communication, information and support for adults with malignant cerebral glioma: a systematic literature review. Support Care Cancer (2003) 11:21–9. doi:10.1007/s00520-002-0392-x

PubMed Abstract | CrossRef Full Text | Google Scholar

36. Janssen DJ, Spruit MA, Schols JM, Cox B, Nawrot TS, Curtis JR, et al. Predicting changes in preferences for life-sustaining treatment among patients with advanced chronic organ failure. Chest (2012) 141:1251–9. doi:10.1378/chest.11-1472

PubMed Abstract | CrossRef Full Text | Google Scholar

37. Higginson IJ, Sen-Gupta GJ. Place of care in advanced cancer: a qualitative systematic literature review of patient preferences. J Palliat Med (2000) 3(3):287–300. doi:10.1089/jpm.2000.3.287

PubMed Abstract | CrossRef Full Text | Google Scholar

38. Tang ST. When death is imminent: where terminally ill patients with cancer prefer to die and why. Cancer Nurs (2003) 26(3):245–51. doi:10.1097/00002820-200306000-00012

PubMed Abstract | CrossRef Full Text | Google Scholar

39. Moore G, Collins A, Brand C, Gold M, Lethborg C, Murphy M, et al. Palliative and supportive care needs of patients with high-grade glioma and their carers: a systematic review of qualitative literature. Patient Educ Couns (2013) 91:141–53. doi:10.1016/j.pec.2012.11.002

PubMed Abstract | CrossRef Full Text | Google Scholar

40. Lin E, Rosenthal MA, Le BH, Eastman P. Neuro-oncology and palliative care: a challenging interface. Neuro Oncol (2012) 14(Suppl4):iv3–7. doi:10.1093/neuonc/nos209

CrossRef Full Text | Google Scholar

41. Walbert T, Puduvalli VK, Martin JB, Taphoorn AT, Jalali R. International patterns of palliative care in neuro-oncology: a survey of physician members of the Asian Society for Neuro-Oncology, the European Association of Neuro-Oncology, and the Society for Neuro-Oncology. Neuro Oncol Pract (2015) 2(2):62–9. doi:10.1093/nop/npu037

CrossRef Full Text | Google Scholar

42. Kane GA, Wood VA, Barlow J. Parenting programmes: a systematic review and synthesis of qualitative research. Child Care Health Dev (2007) 33:784–93. doi:10.1111/j.1365-2214.2007.00750.x

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: advance care planning, end-of-life care, communication, glioma, brain tumor

Citation: Song K, Amatya B, Voutier C and Khan F (2016) Advance Care Planning in Patients with Primary Malignant Brain Tumors: A Systematic Review. Front. Oncol. 6:223. doi: 10.3389/fonc.2016.00223

Received: 19 August 2016; Accepted: 07 October 2016;
Published: 24 October 2016

Edited by:

André O. Von Bueren, University of Göttingen, Germany

Reviewed by:

Carsten Friedrich, Leipzig University, Germany
Tobias Walbert, Henry Ford Health System, USA

Copyright: © 2016 Song, Amatya, Voutier and Khan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Krystal Song, krystal.song@mh.org.au