Editorial: Murine Models of Leukemia and Lymphoma
- 1University of Nebraska Omaha, Omaha, NE, United States
- 2Sidney Kimmel Cancer Center, Philadelphia, PA, United States
Editorial on the Research Topic
Murine models serve as an effective way to mimic the in vivo tumor microenvironmental interactions that take place in patients with leukemias and lymphomas. Specifically, leukemias and lymphomas rely heavily on the surrounding stroma and tissue microenvironmental cytokine and chemokine signals to ensure survival and expansion of tumor cells. Finally, leukemic cells migrate thanks to signals from varying regions of the host, furthering the progression and severity of disease. It is therefore impossible to fully understand such a dynamic relationship between tumor cells and their surrounding microenvironment, and the events to transformation in leukemias and lymphomas without an in vivo, or murine model. While many models have been established, their strengths and weaknesses must be realized in order to best interpret findings from each model and ultimately apply that to the clinic. All of this knowledge is useful in determining the etiology of the tumor cells, the plasticity of them, their relationship with the surrounding microenvironment, diagnostic and prognostic markers, as well as serve as a way to test novel therapeutic regimens.
All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Keywords: murine models, leukemia, lymphoma, tumor cell plasticity, cytokines/chemokines
Citation: Cutucache CE and Porcu P (2017) Editorial: Murine Models of Leukemia and Lymphoma. Front. Oncol. 7:309. doi: 10.3389/fonc.2017.00309
Received: 25 October 2017; Accepted: 29 November 2017;
Published: 08 December 2017
Edited by:Sara Galimberti, University of Pisa, Italy
Reviewed by:Giuseppe Alberto Palumbo, Policlinico Universitario di Catania, Italy
Copyright: © 2017 Cutucache and Porcu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Christine E. Cutucache, firstname.lastname@example.org