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Front. Oncol. | doi: 10.3389/fonc.2018.00012

Intraoperative Radiation ‘Boost’ to the Surgical Resection Bed following Pancreaticoduodenectomy for a Borderline Resectable Pancreatic Carcinoma: A Case Report

  • 1Radiation Oncology, Loyola University, United States

Neoadjuvant therapy including chemotherapy alone or concurrent chemotherapy with external bream radiation is a standard treatment strategy for borderline resectable pancreatic adenocarcinoma and is also used routinely for primary operable cancers at some institutions1. The use of intraoperative radiation therapy (IORT) has been limited largely because of the logistical issues in delivery of radiation during surgery2. This is the first reported case of a borderline resectable pancreas cancer patient who underwent neoadjuvant chemo-radiation therapy followed by resection with the use of IORT using the mobile IntraBeam Device to boost the resection bed and improve local control by dose escalation.

Keywords: Intraoperative radiation therapy, IORT, pancreas cancer, Borderline resectable, Neoadjuvant Therapy

Received: 07 Apr 2017; Accepted: 16 Jan 2018.

Edited by:

Brian T. Collins, School of Medicine, Georgetown University, United States

Reviewed by:

Joseph M. Herman, Johns Hopkins University, United States
Thomas Kole, Valley Hospital, United States  

Copyright: © 2018 Thomas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Tarita O. Thomas, THOMAS., Loyola University, Radiation Oncology, 2160 S 1st Ave, Maguire Center, Rm 2932, 2 East Erie Street, # 3803, Maywood, 60153, IL, United States, tathomas@lumc.edu