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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2018.00618

Promising Clinical Outcome with Long Term Follow-Up after Body Gamma Knife Stereotactic Radiosurgery for Patients with Early Stage Non-Small Cell Lung Cancer

  • 1Air Force General Hospital PLA, China

Introduction: Stereotactic ablative radiosurgery (SRS) or stereotactic ablative body radiotherapy (SABR) is the standard treatment for patients with inoperable early stage non-small cell lung cancer (NSCLC), the body gamma knife SRS (ɣ-SRS) is a special SABR technology developed in China. This study prospectively assessed the clinical outcome, toxicity and cost following body ɣ-SRS for early stage NSCLC.

Methods: From 2007 to 2010, a total of 29 patients with early stage NSCLC were prospectively enrolled in this study. The prescription dose for Planning Target Volume (PTV), Clinical Target Volume (CTV) and Gross Target Volume (GTV) were 50, 60, and 70 gray (Gy) in 10 fractions. 50%, 60%, and 70% isodose curve covered at least 100% of PTV, 90% of CTV, and 80% of GTV. The body ɣ-SRS was delivered 5 days per week and completed in 2 weeks.

Results: Median follow-up time is 62.0 (range 11.1-124.0) months. 1-, 3-, 5-year OS rates were 93.1%, 72.0%, 60.3%, PFS rates were 86.2%, 64.2% and 48.8%, LR, RR, and DM rates were 10.9%, 21.4%, 29.0%. The median cost of the body ɣ-SRS during treatment was 4838 (range 4615-4923) dollars, median cost through 5 years was 36960 (range 9920-56824) dollars.

Conclusion: With existing clinical data, the body ɣ-SRS is an effective treatment option for patients with medically inoperable early stage NSCLC or patients not prefer operation, they may derive benefit from minimized toxicity. Due to excellent cost effectiveness, the availability of the body ɣ-SRS will expand, especially in the developing nations and underdeveloped countries.

Keywords: Early stage lung cancer, Non-small cell lung cancer, body gamma knife, Stereotactic ablative body radiation therapy (SABR), Stereotactic body radiotherapy (SBRT), Stereotactic radiosurgery (SRS)

Received: 02 Oct 2018; Accepted: 29 Nov 2018.

Edited by:

Brian T. Collins, School of Medicine, Georgetown University, United States

Reviewed by:

Seth Blacksburg, Winthrop University, United States
Michael C. Repka, Winthrop University Hospital, United States  

Copyright: © 2018 Li, Li, Wang, Pang, Di, Ren, Li, Chen, Kang, Liu, Wang and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Yingjie Wang, Air Force General Hospital PLA, Beijing, 100142, Beijing Municipality, China,
Dr. Tingyi Xia, Air Force General Hospital PLA, Beijing, 100142, Beijing Municipality, China,