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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2018.00639

Optimal Extent of Transhiatal Gastrectomy and Lymphadenectomy for the Stomach-predominant Adenocarcinoma of Esophagogastric Junction: Retrospective Single-institution Study in China

 Baoyu Zhao1, 2, Hao Liu3, Tian Lin3, Hao Chen3, Yanfeng Hu3, Tingyu Mou3, Jiang Yu3* and Guoxin Li3*
  • 1Department of Gastroenterology, Nanfang Hospital, Southern Medical University, China
  • 2Shanxi Provincial People's Hospital, China
  • 3Nanfang Hospital, Southern Medical University, China

Background. The optimal extent of gastrectomy and lymphadenectomy for esophagogastric junction (EGJ) cancer is controversial. Our study aimed to compare the long-term survival of transhiatal proximal gastrectomy with extended periproximal lymphadenectomy (THPG with EPL) and transhiatal total gastrectomy with complete perigastric lymphadenectomy (THTG with CPL) for patients with the stomach-predominant form of EGJ cancer.

Methods. Between January 2004, and August 2015, 306 patients with Siewert II tumors were divided into the THTG group (n=148) and the THPG group (n=158). Their long-term survival was compared according to Nishi’s classification. The Kaplan–Meier method and Cox proportional hazards models were used for survival analysis.

Results. There were no significant differences between the two groups in the distribution of age, gender, tumor size or Nishi’s type (P>0.05). However, a significant difference was observed in terms of pathological tumor stage (P<0.05). The 5-year overall survival rates were 62.0% in the THPG group and 59.5% in the THTG group. The hazard ratio for death was 0.455 (95% CI, 0.337 to 0.613; log-rank P<0.001). Type GE/E=G showed a worse prognosis compared with Type G (P<0.05). Subgroup analysis stratified by Nishi’s classification, Stage IA-IIB and IIIA, and tumor size ≤ 30 mm indicated significant survival advantages for the THPG group (P<0.05). However, this analysis failed to show a survival benefit in Stage IIIB (P=0.211).

Conclusions. Nishi's classification is an effective method to clarify the subdivision of Siewert II tumors with a diameter ≤ 40 mm above or below the EGJ. THPG with EPL is an optimal procedure for patients with stomach-predominant EGJ tumors less than 30 mm in diameter and in Stage IA-IIIA. For more advanced and larger EGJ tumors, further studies are required to confirm the necessity of THTG with CPL.

Keywords: Esophagogastric Junction, Stomach-predominant Adenocarcinoma, Transhiatal Gastrectomy, Lymphadenectomy, Niahi‘s classification, Siewert's classification

Received: 24 Sep 2018; Accepted: 06 Dec 2018.

Edited by:

Zongbing You, Tulane University, United States

Reviewed by:

Lunxu Liu, West China Hospital, Sichuan University, China
Long-Qi Chen, West China Hospital, Sichuan University, China  

Copyright: © 2018 Zhao, Liu, Lin, Chen, Hu, Mou, Yu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Jiang Yu, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, China, balbc@163.com
Prof. Guoxin Li, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, China, gzliguoxin@163.com