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Front. Oncol. | doi: 10.3389/fonc.2019.00015

Progression on citrullination of proteins in gastrointestinal cancers

  • 1Ruijin Hospital, China
  • 2Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, China

The citrullination modification (Cit) of proteins has received increasing attention in recent years. This kind of protein modification was first discovered in autoimmune diseases such as rheumatoid arthritis. The citrullination modification process is catalyzed by the peptidyl arginine deiminases (PADIs) family. A well-known citrullination of histone involves the key mechanism of neutrophil extracellular traps (NETs) of inflammation in the peripheral blood. Further studies revealed that citrullination modification of proteins also involves in carcinogenesis in human being. Citrullinated proteins disturbed the stability of proteins and caused DNA damages. There is increasing evidence that citrullinated proteins can be used as potential targets for cancer diagnosis or treatment. This review introduces the concept of citrullination modification of proteins, substrate proteins, examining methods and biological significances.

Keywords: citrullination, Proteins, histone, PADIs, molecular targets

Received: 18 Nov 2018; Accepted: 04 Jan 2019.

Edited by:

Zhe-Sheng Chen, St. John's University, United States

Reviewed by:

Qi Liu, Tongji University, China
Kathy K. LI, Georgia State University, United States
Qingyuan Zhang, Ningxia Medical University, China  

Copyright: © 2019 Yu and SONG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Yingyan Yu, Ruijin Hospital, Shanghai, China, ruijinhospitalyyy@163.com