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Front. Oncol. | doi: 10.3389/fonc.2019.00028

Prognostic and risk stratification value of lesion MACC1 expression in colorectal cancer patients

 Wei-Hua Yan1*, Aifen Lin1, Xia Zhang1, Rui- Li Zhang1, Xiao-Fang He2 and Jian-Gang Zhang1
  • 1Taizhou Hospital, Wenzhou Medical University, China
  • 2Lanxi People's Hospital, China

The up-regulated metastasis-associated in colon cancer 1 (MACC1) expression and its clinical significance has been explored in a varity of malignancies. In this study, lesion MACC1 expression in 503 CRC patients (Ncolon=332, Nrectal=171) were analyzed with immunohistochemistry, and its correlation with clinical parameters, patient survival, and its impact on prognostic stratification were evaluated. Data revealed the survival of patient with MACC1high is markedly worse than that of MACC1low (mean overall survival: 80.1 months vs. 90.4 months; p=0.001) and is an independent prognostic predictor (hazard ratio=1.533; p=0.005). More importantly, for the first time, we demonstrated that MACC1 status exhibited a significantly prognostic power for stratified clinical parameters such as patient age and gender, particular TNM status and distinct AJCC disease stage. In summary, our findings indicated that MACK is a valuable prognostic and risk stratification biomarker for colorectal cancer patients.

Keywords: MACC1, colorectal cancer, Survival, prognosis, risk stratification

Received: 22 Nov 2018; Accepted: 10 Jan 2019.

Edited by:

Cornelis F. Sier, Leiden University, Netherlands

Reviewed by:

Ludovic Barault, University of Turin, Italy
Pim J. Koelink, University Medical Center Amsterdam, Netherlands  

Copyright: © 2019 Yan, Lin, Zhang, Zhang, He and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Wei-Hua Yan, Taizhou Hospital, Wenzhou Medical University, Linhai, China, yanwhcom@yahoo.com