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Systematic Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.00675

Enhanced Recovery after Surgery for Breast Reconstruction: Pooled Meta-Analysis of 10 Observational Studies involving 1838 Patients

 Ya-Zhen Tan1, Xuan Lu1, Jie Luo1,  Zhen-Dong Huang1, Qi-Feng Deng1,  Chao Zhang1* and  Xian-Feng Shen1
  • 1Taihe Hospital, Hubei University of Medicine, China

Purpose: This study aimed to explore the effectiveness and safety of the enhanced recovery after surgery (ERAS) protocol versus traditional perioperative care programs for breast reconstruction.
Methods: Three electronic databases (PubMed, EMBASE, and Cochrane Library) were searched for observational studies comparing an ERAS program with a traditional perioperative care program from database inception to May 5, 2018. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data, and evaluated study quality using the Newcastle-Ottawa Scale. Subgroup and sensitivity analyses were performed. The outcomes included length of hospital stay (LOS), complication rates, pain control, costs, emergency department visits, hospital readmission, and unplanned reoperation.
Results: Ten studies were included in the meta-analysis. Compared with a conventional program, ERAS was associated with significantly decreased LOS, morphine administration (including postoperative patient-controlled analgesia usage rate and duration; intravenous morphine administration on postoperative day [POD] 0, 1, 2, and 4; total intravenous morphine administration on POD 0–3; oral morphine consumption on POD 0–4; and total postoperative oral morphine consumption), and pain scores (postoperative pain score on POD 0 and total pain score on POD 0–3). The other variables did not differ significantly.
Conclusion: Our results suggest that ERAS protocols can decrease LOS and morphine equivalent dosing; therefore, further larger and better-quality studies that report bleeding amount and patient satisfaction are needed to validate our findings.

Keywords: Breast reconstruction, Enhanced recovery after surgery, pain control, flap loss, complication

Received: 28 Feb 2019; Accepted: 10 Jul 2019.

Edited by:

Aali J. Sheen, Department of General Surgery, Manchester Royal Infirmary, United Kingdom

Reviewed by:

Lunxu Liu, West China Hospital, Sichuan University, China
Laura Kruper, City of Hope National Medical Center, United States  

Copyright: © 2019 Tan, Lu, Luo, Huang, Deng, Zhang and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Chao Zhang, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China,