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Front. Oncol. | doi: 10.3389/fonc.2019.00971

Induction of pyroptosis and its implications in cancer management

 Yan-Yang Wang1*, Xin-Lan Liu1 and Ren Zhao1
  • 1General Hospital of Ningxia Medical University, China

Pyroptosis is a gasdermins mediated programmed cell death, which has been widely studied in inflammatory disease models. Recently, there are growing evidences that pyroptosis can be chemically induced in cancer cells without any bacterial or viral infection. Pyroptosis may affect all stages of carcinogenesis and has become a new topic in cancer research. In this review, we first briefly introduced pyroptosis. In the subsequent section, we discussed the induction of pyroptosis in cancer and its potential role as a promising target for cancer therapy. In addition, the biological characteristics of gasdermin D (GSDMD) and gasdermin E (GSDME), two important pyroptosis substrates, and their prognostic role in cancer management were reviewed. These results help us to understand the pathogenesis of cancer and develop new drugs, which based on pyroptosis modulation, for cancer patients.

Keywords: pyroptosis, GSDMD, GSDME, Cancer Progression, Therapeutic sensitivity

Received: 07 May 2019; Accepted: 12 Sep 2019.

Copyright: © 2019 Wang, Liu and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Yan-Yang Wang, General Hospital of Ningxia Medical University, Yinchuan, China, fdwyy1981@hotmail.com