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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01012

Review of the clinical evidences of modulated electro-hyperthermia (mEHT) method: an update for the practicing oncologist

 Attila M. Szasz1*, Carrie Minnaar2,  Gyongyver Szentmartoni1, Gyula P. Szigeti1 and Magdolna Dank1
  • 1Semmelweis University, Hungary
  • 2University of the Witwatersrand, South Africa

Background: Modulated electro-hyperthermia (mEHT) is a variation of the conventional hyperthermia which selectively targets the malignant cell membranes in order to heat the malignant tissue and sensitise the tissue to oncology treatments. Although widely applied, the formulation of guidelines for the use thereof is still in progress for many tumours.

Aim: In this paper we review the literature on the effects of mEHT in cancer patients on local disease control and survival.

Methodology: Our review on data presents the collected experience with capacitive hyperthermia treatments with the EHY-2000+ device (OncoTherm Ltd., Germany). A literature search was conducted in Pubmed and articles were grouped and discussed according to: trial type, animal studies, in vitro studies, and reviews. Search results from Conference Abstracts; Trial Registries; Thesis and Dissertations and the Oncothermia Journal were included in the discussions.

Results: Modulated electro-hyperthermia is a safe form of hyperthermia which has shown to effectively sensitizes deep tumors, regardless of the thickness of the adipose layers. The technology has demonstrated equal benefits compared to other forms of hyperthermia for a variety of tumors. Given the effective heating ability to moderate temperatures, the improved tumor perfusion, and ability to increase drug absorption, mEHT is a safe and effective heating technology which can be easily applied to sensitize tumors which have demonstrated benefits with the addition of hyperthermia. Modulated electro-hyperthermia also appears to improve local control and survival rates and appears to induce an abscopal (systemic) response to ionizing radiation.

Conclusion: Based on clinical studies, the method mEHT is a feasible hyperthermia technology for oncological applications. Concomitant utilization of mEHT is supported by the preclinical and clincal data.

Keywords: Selective heating, abscopal effect, hyperthermia (HT), Apoptosis, clinical

Received: 25 Apr 2019; Accepted: 20 Sep 2019.

Copyright: © 2019 Szasz, Minnaar, Szentmartoni, Szigeti and Dank. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Attila M. Szasz, Semmelweis University, Budapest, 1085, Hungary,