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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01051

Revising incidence and mortality of lung cancer in Central-Europe: An epidemiology overview from Hungary

Krisztina Bogos1, Zoltán Kiss2*, Gabriella Galffy1, Lilla Tamasi3, Gyula Ostoros1, Veronika Muller3, Laszlo Urban4, Nora Bittner5, Veronika Sarosi6, Aladar Vastag2, Zsofia Nagy-Erdei2, Zoltan Polanyi2, Zoltan Voko7,  Krisztian Horvath7, Balazs Nagy7,  Gyorgy Rokszin8,  Zsolt Abonyi-Tóth8, 9 and  Judit Moldvay1
  • 1National Koranyi Institute of TB and Pulmonology (Hungary), Hungary
  • 2MSD Pharma Hungary, Hungary
  • 3Semmelweis University, Hungary
  • 4Mátra Medical Institute University of Debrecen Medical and Health Education Hospital, Hungary
  • 5University of Debrecen, Hungary
  • 6University of Pécs, Hungary
  • 7Eötvös Loránd University, Hungary
  • 8RxTarget Ltd, Hungary
  • 9University of Veterinary Medicine Budapest, Hungary

Objective: While Hungary is often reported to have the highest incidence and mortality rates of lung cancer, until 2018 no nationwide epidemiology study was conducted to confirm these figures. The objective of this study was to estimate the occurrence of lung cancer in Hungary based on a retrospective review of the National Health Insurance Fund (NHIF) database.
Methods: Our retrospective, longitudinal study included patients aged ≥20 years who were diagnosed with lung cancer (ICD-10 C34) between 1 Jan 2011 and 31 Dec 2016. Age-standardized incidence and mortality rates were calculated using both the 1976 and 2013 European Standard Populations (ESP).
Results: Between 2011 and 2016, 6,996 to 7,158 new lung cancer cases were recorded in the NHIF database annually, and 6,045 to 6,465 all-cause deaths occurred per year. Age-adjusted incidence rates were 115.7–101.6/100,000 person-years among men (ESP 1976: 84.7–72. 6), showing a mean annual change of -2.26% (p=0.008). Incidence rates among females increased from 48.3 to 50.3/100,000 person-years (ESP 1976: 36.9–38.0) (mean annual change of 1.23%; p=0.028). Age-standardized mortality rates varied between 103.8 and 97.2/100,000 person-years (ESP 1976: 72.8–69.7) in men and between 38.3 and 42.7/100,000 person-years (ESP 1976: 27.8–29.3) in women.
Conclusion: Age-standardized incidence and mortality rates of lung cancer in Hungary were found to be high compared to Western-European countries, but lower than those reported by previous publications. The incidence of lung cancer decreased in men, while there was an increase in incidence and mortality among female lung cancer patients.

Keywords: lung cancer, Incidence, Mortality, Epidemiology, European Standard Population, Hungary

Received: 15 Aug 2019; Accepted: 26 Sep 2019.

Copyright: © 2019 Bogos, Kiss, Galffy, Tamasi, Ostoros, Muller, Urban, Bittner, Sarosi, Vastag, Nagy-Erdei, Polanyi, Voko, Horvath, Nagy, Rokszin, Abonyi-Tóth and Moldvay. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Zoltán Kiss, MSD Pharma Hungary, Budapest, Hungary, zoltan_kiss2@merck.com