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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01089

FA2H Exhibits Tumor Suppressive Roles on Breast Cancers via Cancer Stemness Control

 Xiaofeng Dai1*, Shuo Zhang2, Hongye Cheng2,  Dongyan Cai3,  Xiao Chen2 and  Zhaohui Huang3
  • 1Jiangnan University, China
  • 2School of Biotechnology, Jiangnan University, China
  • 3Affiliated Hospital of Jiangnan University, China

Background: Triple negative breast cancers are aggressive, enriched with cancer stem cells, and lack effective targeted therapies with little side effects.
Methods: We isolated cancer stem cells from two triple negative breast cancer cell lines via cell sorting following transcriptome sequencing, bioinformatics analysis, experimental and clinical validations, as well as functional investigations to explore genes capturing triple negative breast cancer features for improved diagnosis and therapeutics in clinics.
Results: We found that FA2H is under-expressed in triple negative breast cancers both in vitro and in clinics, and FA2H suppresses cancer stemness via inhibiting the STAT3/IL6 axis and NFkB signaling.
Conclusions: This study reports the tumor suppressive roles of FA2H on breast cancer cells through cancer stemness control. FA2H and other candidates unveiled in this study that capture the features of cancer stem cells may contribute as diagnostic marker and/or effective therapeutic targets for improved triple negative breast cancer management.

Keywords: Cancer stem cell, Triple negative breast cancer, FA2H, tumor suppressive role, STAT3/IL6

Received: 22 Jul 2019; Accepted: 02 Oct 2019.

Copyright: © 2019 Dai, Zhang, Cheng, Cai, Chen and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Xiaofeng Dai, Jiangnan University, Wuxi, China,