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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01099

LncRNAs: The Regulator of Glucolipid Metabolism in Tumor Cells

 Wei Lu1,  Shengjun Wang1, Xiumei Sheng1* and  Jie Ma1*
  • 1Jiangsu University, China

Metabolism is a complex network of regulatory systems. Cells often alter their metabolism in response to the changes of their environments. These adaptive changes are particularly pronounced in tumor cells, known as metabolic reprogramming. Metabolic reprogramming is considered to be one of the top ten characteristics of tumor cells. A large number of experimental studies have shown that long non-coding RNAs (lncRNAs) play an important role in glucolipid metabolism of tumor cells. The current review briefly introduces the regulation effect of lncRNAs on glucose and lipid metabolism of tumor cells, and the significance of lncRNAs-mediated metabolism in tumor therapy, hoping to provide new strategies for clinical targeting tumor therapy.

Keywords: lncRNAs, tumor, Glucose, Lipid, Metabolism, therapy

Received: 19 Jul 2019; Accepted: 07 Oct 2019.

Copyright: © 2019 Lu, Wang, Sheng and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Xiumei Sheng, Jiangsu University, Zhenjiang, 212013, Jiangsu Province, China, shengxiumei@ujs.edu.cn
Prof. Jie Ma, Jiangsu University, Zhenjiang, 212013, Jiangsu Province, China, jsdxmajie@ujs.edu.cn