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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01104

Therapeutic strategies targeting cancer stem cells and their microenvironment

 Haoran Sun1, 2, Shun Wang1, 2,  Shican Yan1, 2, Yu Zhang1, 2,  Peter J. Nelson3, Huliang Jia1, 2, Lunxiu Qin1, 2* and  Qiongzhu Dong1, 2*
  • 1Department of General Surgery, Huashan Hospital, Fudan University, China
  • 2Institute of Biomedical Sciences, Fudan University, China
  • 3Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Germany

Cancer stem cells (CSCs) have been demonstrated in a variety of tumors and are thought to act as a clonogenic core for the genesis of new tumor growth. This small subpopulation of cancer cells has been proposed to help drive tumorigenesis, metastasis, recurrence and conventional therapy resistance. CSCs show self-renewal and flexible clonogenic properties, that reflect specific tumor microenvironments (TME). The interaction between CSCs and TME is thought to act as a dynamic support system that fosters the generation and maintenance of CSCs. Investigation of the interaction between CSCs and the TME is shedding light on the biologic mechanisms underlying the process of tumor malignancy, metastasis, and therapy resistance. We summarize recent advances in CSC biology and their environment, and discuss the challenges and future strategies for targeting this biology as a new therapeutic approach.

Keywords: cancer stem cells (CSCs), Tumor microenvironments, therapeutic resistance, Mechanism, strategy

Received: 26 Jun 2019; Accepted: 07 Oct 2019.

Copyright: © 2019 Sun, Wang, Yan, Zhang, Nelson, Jia, Qin and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mx. Lunxiu Qin, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, Shanghai Municipality, China, qinlx99@vip.163.com
Mx. Qiongzhu Dong, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, Shanghai Municipality, China, qzhdong@fudan.edu.cn