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Systematic Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01111

Prognostic value of programmed cell death ligand-1 expression in nasopharyngeal carcinoma: a meta-analysis of 1315 patients

Xiaofeng Liu1, Chunguang Shan2,  Yingluan Song1* and Juan Du1
  • 1Children's Hospital of Hebei Province, China
  • 2Second Hospital of Hebei Medical University, China

Background: The prognostic value of programmed cell death ligand-1 (PD-L1) in patients with nasopharyngeal carcinoma (NPC) remains controversial. Therefore, we conducted this meta-analysis to understand the role of PD-L1 in NPC.
Method: We searched PubMed, Embase, Web of Science, and Cochrane Library up to April 2019. We determined the pooled hazard ratio (HR) and 95% confidence intervals (CIs) to assess the relationship between PD-L1 and various survival outcomes. Begg’s funnel plot was used to assess any publication bias.
Results: Eleven studies involving 1315 patients were included in this meta-analysis. For overall survival (OS), the HR was 1.48 and 95% CI was 1.00–2.18 (p=0.049). For disease-free survival (DFS), the HR was 1.51 and 95% CI was 0.85–2.69 (p=0.162). For distant metastasis-free survival (DMFS), the HR was 1.75 and 95% CI was 0.64–4.79 (p=0.277). For local recurrence-free survival (LRFS), the HR was 0.67 and 95% CI was 0.06–8.16, (p=0.756). The results of prognosis of PD-L1 and OS were more significant after sensitivity analysis. The pooled odds ratio indicated that PD-L1 expression was not associated with T stage, N stage, M stage, overall stage, sex, age, smoking, or alcohol intake. No publication bias was found.
Conclusion: Our meta-analysis showed that PD-L1 overexpression in NPC was associated with a poor OS and may be useful as a novel prognostic factor for NPC.

Keywords: PD-L1, Meta-analysis, prognosis, nasopharyngeal carcinoma, clinical use

Received: 15 Jul 2019; Accepted: 07 Oct 2019.

Copyright: © 2019 Liu, Shan, Song and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Yingluan Song, Children's Hospital of Hebei Province, Shijiazhuang, Hebei Province, China, xee675@163.com