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Hypothesis and Theory ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01115

Insights into mechanisms of tumor and immune system interaction: association with wound healing

  • 1Russian Cancer Research Center NN Blokhin, Russia

A large number of studies have presented a great deal of information about tumor and immune system interaction. Nevertheless, the problem of tumor evasion from the immune reaction is still difficult to resolve. Understanding the ways of how immunosuppressive tumor microenvironment develops and maintains its potential is of utmost importance for the best use of the suppressed immune functions. The study presents a review covering the data on tumor-associated antigens, mechanisms of tumor evasion from the immune reactions, and search for common immunosuppressive processes of tumor growth and normal wound healing. The study discusses the important role of monocytes/macrophages in the regulation of the immune system reactions. We suggest that simultaneous action of growth factors and pro-inflammatory cytokines may result in suppression of the immune system. The study describes intracellular signaling molecules that take part in the regulation of the myeloid cell functions. If the hypothesis is proved, the indicated interaction of cytokines could be regarded as a prospective target for antitumor therapy.

Keywords: Monocytes, Macrophages, hypothesis, Inflammation, growth factors, Immunosuppression, tumor, Wound Healing

Received: 17 Jul 2019; Accepted: 07 Oct 2019.

Copyright: © 2019 Ponomarev and Shubina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mr. Aleksandr Ponomarev, Russian Cancer Research Center NN Blokhin, Moscow, Russia, kl8546@yandex.ru