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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01176

MiR-9-5p Inhibits Glioblastoma Cells Proliferation Through Directly Targeting FOXP2(forkhead box P2)

 Hongbo Zhang1, Yuntao Li2, 3,  Yinqiu Tan2, Qi Liu4, Shuting Jiang2, Dongyuan Liu2,  Qianxue Chen2* and  Shizhong Zhang5*
  • 1Department of Neurosurgery, Zhujiang hospital, Southern Medical University, China
  • 2Department of Neurosurgery, Renmin Hospital of Wuhan University, China
  • 3Department of Neurosurgey, Huzhou Central Hospital, China
  • 4Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, China
  • 5Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, China

Glioblastoma (GBM) is the most malignant tumor in the central nervous system and the treatment is still unsatisfactory because the mechanism of the disease remains unclear. The abnormal expression of miRNAs and its target proteins play a crucial role in the development of glioblastoma. In this study, we demonstrated that high expression of miR-9-5p and low expression of forkhead box P2 (FOXP2) were related with better outcome in patients with GBM, and down regulated FOXP2 expression was able to inhibit glioma cells proliferation by cell cycle arrest . Furthermore, we found that FOXP2 was the target protein of miR-9-5p in luciferase assay. The results of this study suggest a novel regulatory mechanism that miR-9-5p can inhibit glimo cells proliferation by downregulating FOXP2.

Keywords: miR-9-5p, FoxP2, Glioblastoma, proliferation, Glioma

Received: 07 May 2019; Accepted: 18 Oct 2019.

Copyright: © 2019 Zhang, Li, Tan, Liu, Jiang, Liu, Chen and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Qianxue Chen, Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430072, Hubei Province, China,
Prof. Shizhong Zhang, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China,