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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01263

A new era in Prostate cancer precision medicine

Adil Malik1, 2, 3,  Srilakshmi Srinivasan1, 2, 3 and  Jyotsna Batra1, 2, 3*
  • 1Queensland University of Technology, Australia
  • 2Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
  • 3Translational Research Institute, University of Queensland, Australia

Prostate Cancer is the second most common male cancer affecting Western society. Despite substantial advances in the exploration of Prostate Cancer biomarkers and treatment strategies, men are over diagnosed with inert Prostate Cancer, while there is also a substantial mortality from the invasive disease. Precision medicine is the management of treatment profiles across different cancers predicting therapies for individual cancer patients. Strategies including individual genomic profiling and targeting specific cancer pathways, precision medicine for Prostate Cancer has the potential to impose changes in clinical practices. Some of the recent advances in Prostate Cancer precision medicine comprise targeting gene fusions, genome editing tools, non-coding RNA biomarkers and the promise of liquid tumour profiling. In this review, we will discuss these recent scientific advances to scale up these approaches and endeavours to overcome clinical barriers for Prostate Cancer precision medicine.

Keywords: prostate cancer, precision medicine, Gene Fusion, biomarkers, Proteomic technologies, Genome editing, Non coding genome, liquid biopsy

Received: 06 Jun 2019; Accepted: 31 Oct 2019.

Copyright: © 2019 Malik, Srinivasan and Batra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Jyotsna Batra, Queensland University of Technology, Brisbane, Australia, jyotsna.batra@qut.edu.au