Original Research ARTICLE
PA28α/β Promote Breast Cancer Cell Invasion and Metastasis via Down-regulation of CDK15
- 1Southern Medical University, China
PA28α/β activated immunoproteasome frequently participates in MHC class I antigen processing, however, whether it is involved in breast tumor progression remains largely unclear. Here, our evidences show that PA28α/β proteins are responsible for breast cancer cell migration and invasion in vitro as well as metastasis in vivo. Knockdown of immunoproteasome core subunit β5i also robustly suppresses the tumor cell migration and invasion. Interestingly, silencing of PA28α/β and β5i up-regulates the protein expression of cyclin-dependent kinase 15 (CDK15). Our data further indicate that the loss of CDK15 is important for breast tumor cell invasion and metastasis. Taken together, this study implicates that targeting of PA28α/β represents a potential way for treatment of metastatic breast cancer.
Keywords: breast cancer, invasion, metastasis, PA28α/β, CDK15
Received: 21 Jul 2019;
Accepted: 05 Nov 2019.
Copyright: © 2019 Shi, Li, Dai, Gong, Song and Tai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Jian Shi, Southern Medical University, Guangzhou, China, firstname.lastname@example.org