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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01283

PA28α/β Promote Breast Cancer Cell Invasion and Metastasis via Down-regulation of CDK15

 Jian Shi1*, Shengnan Li1, Xiaoqin Dai1, Kunxiang Gong1, Kai Song1 and Fang Tai1
  • 1Southern Medical University, China

PA28α/β activated immunoproteasome frequently participates in MHC class I antigen processing, however, whether it is involved in breast tumor progression remains largely unclear. Here, our evidences show that PA28α/β proteins are responsible for breast cancer cell migration and invasion in vitro as well as metastasis in vivo. Knockdown of immunoproteasome core subunit β5i also robustly suppresses the tumor cell migration and invasion. Interestingly, silencing of PA28α/β and β5i up-regulates the protein expression of cyclin-dependent kinase 15 (CDK15). Our data further indicate that the loss of CDK15 is important for breast tumor cell invasion and metastasis. Taken together, this study implicates that targeting of PA28α/β represents a potential way for treatment of metastatic breast cancer.

Keywords: breast cancer, invasion, metastasis, PA28α/β, CDK15

Received: 21 Jul 2019; Accepted: 05 Nov 2019.

Copyright: © 2019 Shi, Li, Dai, Gong, Song and Tai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Jian Shi, Southern Medical University, Guangzhou, China, jianshismu@126.com