%A Na,Lei %A Bai,Yu %A Sun,Yu %A Wang,Zhuo %A Wang,Wei %A Yuan,Lin %A Zhao,Chenghai %D 2020 %J Frontiers in Oncology %C %F %G English %K immune,bladder urothelial carcinoma(bladder cancer),prognosis,overall survival,TCGA %Q %R 10.3389/fonc.2020.01142 %W %L %M %P %7 %8 2020-July-08 %9 Original Research %# %! Immune-related genes of bladder carcinoma %* %< %T Identification of 9-Core Immune-Related Genes in Bladder Urothelial Carcinoma Prognosis %U https://www.frontiersin.org/articles/10.3389/fonc.2020.01142 %V 10 %0 JOURNAL ARTICLE %@ 2234-943X %X Background: Immune microenvironment within tumors affects initiation, progression and clinical outcome of human cancers. Here we explored an immune-related gene signature associated with prognosis of patients with bladder urothelial carcinoma.Method: The Cancer Genome Atlas (TCGA) database was interrogated for expressions of immune-related genes in bladder urothelial carcinomas. Integrated bioinformatics analyses were performed to identify prognostic factors.Results: Twenty-seven immune-related genes were revealed significantly associated with patient's overall survival (OS) by univariate Cox proportional hazards regression analysis. Nine-core immune-related genes including MMP9, PDGFRA, AHNAK, OLR1, RAC3, IGF1, PGF, OAS1, and SH3BP2 were selected to construct a risk score model by multivariate Cox proportional hazards regression analysis. Bioinformatics analyses further validated that risk score could be used as an important independent factor in evaluating prognosis.Conclusion: We established a prognostic immune signature for patients with bladder urothelial carcinoma, which may provide novel targets for prediction and therapy of these patients.