%A Spolverato,Gaya
%A Capelli,Giulia
%A Battagello,Jessica
%A Barina,Andrea
%A Nordio,Susi
%A Finotti,Elena
%A Mondi,Isabella
%A Da Lio,Corrado
%A Morpurgo,Emilio
%A Navarro,Josè Adolfo
%A Ceccato,Fabio
%A Perin,Alessandro
%A Pedrazzani,Corrado
%A Turri,Giulia
%A Zanus,Giacomo
%A Campi,Michela
%A Massani,Marco
%A Di Giacomo,Adriana
%A Prando,Daniela
%A Agresta,Ferdinando
%A Pucciarelli,Salvatore
%A Zorzi,Manuel
%A Rugge,Massimo
%D 2021
%J Frontiers in Oncology
%C
%F
%G English
%K colorectal cancer,Surgery,screening,colorectal cancer outcomes,Disease free survival,overall survival
%Q
%R 10.3389/fonc.2021.620644
%W
%L
%M
%P
%7
%8 2021-March-15
%9 Original Research
%+ Salvatore Pucciarelli,Department Surgical, Oncological and Gastroenterological Sciences, University of Padova,Italy,puc@unipd.it
%#
%! Surgical Outcomes of Colorectal Cancer Screening
%*
%<
%T More Favorable Short and Long-Term Outcomes for Screen-Detected Colorectal Cancer Patients
%U https://www.frontiersin.org/articles/10.3389/fonc.2021.620644
%V 11
%0 JOURNAL ARTICLE
%@ 2234-943X
%X BackgroundScreening significantly reduces mortality from colorectal cancer (CRC). Screen detected (SD) tumors associate with better prognosis, even at later stage, compared to non-screen detected (NSD) tumors. We aimed to evaluate the association between diagnostic modality (SD vs. NSD) and short- and long-term outcomes of patients undergoing surgery for CRC.Materials and MethodsThis retrospective cohort study involved patients aged 50–69 years, residing in Veneto, Italy, who underwent curative-intent surgery for CRC between 2006 and 2018. The clinical multi-institutional dataset was linked with the screening dataset in order to define diagnostic modality (SD vs. NSD). Short- and long-term outcomes were compared between the two groups.ResultsOf 1,360 patients included, 464 were SD (34.1%) and 896 NSD (65.9%). Patients with a SD CRC were more likely to have less comorbidities (p = 0.013), lower ASA score (p = 0.001), tumors located in the proximal colon (p = 0.0018) and earlier stage at diagnosis (p < 0.0001). NSD patients were found to have more aggressive disease at diagnosis, higher complication rate and higher readmission rate due to surgical complications (all p < 0.05). NSD patients had a significantly lower Disease Free Survival and Overall Survival (all p < 0.0001), even after adjusting by demographic, clinic-pathological, tumor, and treatment characteristics.ConclusionsSD tumors were associated with better long-term outcomes, even after multiple adjustments. Our results confirm the advantages for the target population to participate in the screening programs and comply with their therapeutic pathways.