%A Spolverato,Gaya %A Capelli,Giulia %A Battagello,Jessica %A Barina,Andrea %A Nordio,Susi %A Finotti,Elena %A Mondi,Isabella %A Da Lio,Corrado %A Morpurgo,Emilio %A Navarro,Josè Adolfo %A Ceccato,Fabio %A Perin,Alessandro %A Pedrazzani,Corrado %A Turri,Giulia %A Zanus,Giacomo %A Campi,Michela %A Massani,Marco %A Di Giacomo,Adriana %A Prando,Daniela %A Agresta,Ferdinando %A Pucciarelli,Salvatore %A Zorzi,Manuel %A Rugge,Massimo %D 2021 %J Frontiers in Oncology %C %F %G English %K colorectal cancer,Surgery,screening,colorectal cancer outcomes,Disease free survival,overall survival %Q %R 10.3389/fonc.2021.620644 %W %L %M %P %7 %8 2021-March-15 %9 Original Research %+ Salvatore Pucciarelli,Department Surgical, Oncological and Gastroenterological Sciences, University of Padova,Italy,puc@unipd.it %# %! Surgical Outcomes of Colorectal Cancer Screening %* %< %T More Favorable Short and Long-Term Outcomes for Screen-Detected Colorectal Cancer Patients %U https://www.frontiersin.org/articles/10.3389/fonc.2021.620644 %V 11 %0 JOURNAL ARTICLE %@ 2234-943X %X BackgroundScreening significantly reduces mortality from colorectal cancer (CRC). Screen detected (SD) tumors associate with better prognosis, even at later stage, compared to non-screen detected (NSD) tumors. We aimed to evaluate the association between diagnostic modality (SD vs. NSD) and short- and long-term outcomes of patients undergoing surgery for CRC.Materials and MethodsThis retrospective cohort study involved patients aged 50–69 years, residing in Veneto, Italy, who underwent curative-intent surgery for CRC between 2006 and 2018. The clinical multi-institutional dataset was linked with the screening dataset in order to define diagnostic modality (SD vs. NSD). Short- and long-term outcomes were compared between the two groups.ResultsOf 1,360 patients included, 464 were SD (34.1%) and 896 NSD (65.9%). Patients with a SD CRC were more likely to have less comorbidities (p = 0.013), lower ASA score (p = 0.001), tumors located in the proximal colon (p = 0.0018) and earlier stage at diagnosis (p < 0.0001). NSD patients were found to have more aggressive disease at diagnosis, higher complication rate and higher readmission rate due to surgical complications (all p < 0.05). NSD patients had a significantly lower Disease Free Survival and Overall Survival (all p < 0.0001), even after adjusting by demographic, clinic-pathological, tumor, and treatment characteristics.ConclusionsSD tumors were associated with better long-term outcomes, even after multiple adjustments. Our results confirm the advantages for the target population to participate in the screening programs and comply with their therapeutic pathways.