@ARTICLE{10.3389/fonc.2021.646399, AUTHOR={Luu, Tuan}, TITLE={Epithelial-Mesenchymal Transition and Its Regulation Mechanisms in Pancreatic Cancer}, JOURNAL={Frontiers in Oncology}, VOLUME={11}, YEAR={2021}, URL={https://www.frontiersin.org/articles/10.3389/fonc.2021.646399}, DOI={10.3389/fonc.2021.646399}, ISSN={2234-943X}, ABSTRACT={As one of the malignancies with high mortality and high insensitivity to existing therapies, pancreatic cancer and mechanisms underlying its progression have received growing scholarly attention. The role of the epithelial-mesenchymal transition (EMT) in pancreatic cancer genesis and metastasis has been reported albeit controversy has remained. Recent insights into further EMT-regulating mechanisms underlying pancreatic cancer contribute to the nexus between EMT and this cancer type. This review will elucidate the role of EMT as a hallmark for pancreatic cancer as well as summarize EMT-regulating factors recently detected as a key advance in the research stream on EMT in pancreatic cancer.} }