%A Gibbs,Marie %A Hertz,Leif %D 2014 %J Frontiers in Pharmacology %C %F %G English %K Serotonin,Glycogenolysis,day-old chick,memory formation,Astrocytes %Q %R 10.3389/fphar.2014.00054 %W %L %M %P %7 %8 2014-April-01 %9 Original Research %+ Dr Marie Gibbs,Monash University,Monash Institute of Pharmaceutical Sciences,Parkville,3052,Australia,marie.gibbs@monash.edu %# %! 5HT2B receptor-induced glycogenolysis and memory formation %* %< %T Serotonin mediation of early memory formation via 5-HT2B receptor-induced glycogenolysis in the day-old chick %U https://www.frontiersin.org/articles/10.3389/fphar.2014.00054 %V 5 %0 JOURNAL ARTICLE %@ 1663-9812 %X Investigation of the effects of serotonin on memory formation in the chick revealed an action on at least two 5-HT receptors. Serotonin injected intracerebrally produced a biphasic effect on memory consolidation with enhancement at low doses and inhibition at higher doses. The non-selective 5-HT receptor antagonist methiothepin and the selective 5-HT2B/C receptor antagonist SB221284 both inhibited memory, suggesting actions of serotonin on at least two different receptor subtypes. The 5-HT2B/C and astrocyte-specific 5-HT receptor agonist, fluoxetine and paroxetine, enhanced memory and the effect was attributed to glycogenolysis. Inhibition of glycogenolysis with a low dose of DAB (1,4-dideoxy-1,4-imino-D-arabinitol) prevented both serotonin and fluoxetine from enhancing memory during short-term memory but not during intermediate memory. The role of serotonin on the 5-HT2B/C receptor appears to involve glycogen breakdown in astrocytes during short-term memory, whereas other published evidence attributes the second period of glycogenolysis to noradrenaline.