%A Lyu,Xuechan %A Du,Jiang %A Zhan,Guilai %A Wu,Yujie %A Su,Hang %A Zhu,Youwei %A Jarskog,Fredrik %A Zhao,Min %A Fan,Xiaoduo %D 2018 %J Frontiers in Pharmacology %C %F %G English %K Schizophrenia,Smoking Cessation,Weight Loss,Naltrexone,Bupropion %Q %R 10.3389/fphar.2018.00181 %W %L %M %P %7 %8 2018-March-05 %9 Clinical Trial %+ Min Zhao,Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine,China,drzhaomin@sh163.net %+ Min Zhao,Shanghai Key Laboratory of Psychotic Disorders,China,drzhaomin@sh163.net %+ Xiaoduo Fan,Psychotic Disorders Program, UMass Memorial Medical Center, University of Massachusetts Medical School,United States,xiaoduo.fan@umassmed.edu %# %! NALTREXONE AND BUPROPION COMBINATION TREATMENT %* %< %T Naltrexone and Bupropion Combination Treatment for Smoking Cessation and Weight Loss in Patients With Schizophrenia %U https://www.frontiersin.org/articles/10.3389/fphar.2018.00181 %V 9 %0 JOURNAL ARTICLE %@ 1663-9812 %X Objective: The rates of obesity and cigarette smoking are much higher in patients with schizophrenia compared to the general population. This study was to examine whether naltrexone and bupropion combination treatment can help weight loss and smoking cessation in patients with schizophrenia.Methods: Obese male schizophrenia patients with current cigarette smoking were randomized to receive adjunctive naltrexone (25 mg/day) and bupropion (300 mg/day) combination or placebo for 24 weeks. Twenty-two patients were enrolled in the study, and 21 patients completed the study (11 in the treatment group, and 10 in the placebo group). Body weight, body mass index (BMI), fasting lipids, smoking urge, expired carbon monoxide (CO) level and cigarettes smoked per week were measured at baseline and week 24.Results: There was no significant difference between two groups in changes in weight, BMI, fasting lipids, or cigarette smoking measures (p's > 0.05)Conclusion: Naltrexone and bupropion combination treatment didn't show weight loss or smoking cessation effect in patients with schizophrenia in this pilot study.Implications for future studies were discussed.ClinicalTrials.gov identifier: NCT02736474.