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This article is part of the Research Topic

Emerging Therapeutic Approaches for Cystic Fibrosis

Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.00024

Unraveling the Function of Lemur Tyrosine Kinase 2 Network

  • 1Department of Nephrology, Children’s Hospital of Pittsburgh, United States
  • 2Institute of Biosystems and Integrative Sciences (BioISI), Portugal

Lemur Tyrosine Kinase 2 (LMTK2) is a recently cloned transmembrane protein, actually a serine/threonine kinase named after the Madagascar primate lemur due to the long intracellular C-terminal tail. LMTK2 is relatively little known, compared to other kinases but its role has been increasingly recognized. Published data show that LMTK2 regulates key cellular events, including endocytic trafficking, nerve growth factor signaling, apoptosis, and Cl- transport. Abnormalities in the expression and function of LMTK2 are associated with human disease, such as neurodegeneration, cancer and infertility. We summarized the current state of knowledge on LMTK2 structure, regulation, interactome, intracellular localization, and tissue expression and point out future research directions to better understand the role of LMTK2.

Keywords: LMTK2, kinase, cystic fibrosis, signaling / signaling pathways, Phosphorylation, PP1

Received: 03 Nov 2018; Accepted: 10 Jan 2019.

Edited by:

Anthony Kicic, Telethon Kids Institute, Australia

Reviewed by:

Hiroshi Hibino, Niigata University, Japan
Hai M. Nguyen, University of California, Davis, United States  

Copyright: © 2019 Cruz, Farinha and Swiatecka-Urban. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mr. Daniel F. Cruz, Department of Nephrology, Children’s Hospital of Pittsburgh, Pittsburgh, United States, dfcruz@fc.ul.pt