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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.00844

Traditional Chinese medicine for coronary heart disease: Clinical evidence and possible mechanisms

 Jian K. Zhang1,  Qun Zheng1, Peng-chong Zhu1, Qiang Tong1, Zhuang Zhuang1,  Jiazhen Zhu1,  Xiao-Yi Bao1,  Yue-yue Huang1,  Guo-qing Zheng2* and  Yan Wang1
  • 1Department of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, China
  • 2Department of Neurology, Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, China

Abstract
Coronary heart disease (CHD) remains a major cause of mortality with a huge economic burden on healthcare worldwide. Here, we conducted a systematic review to investigate the efficacy and safety of Chinese herbal medicine (CHM) for CHD based on high-quality randomized controlled trials (RCTs) and summarized its possible mechanisms according to animal-based researches. Twenty-seven eligible studies were identified in 8 database searches from inception to June 2018. The methodological quality was assessed using 7-item checklist recommended by Cochrane Collaboration. All the data were analyzed using Rev-Man 5.3 software. As a result, the score of study quality ranged from 4 to 7 points. Meta-analyses showed CHM can significantly reduce the incidence of myocardial infarction and percutaneous coronary intervention, and cardiovascular mortality (P< 0.05), increase systolic function of heart, the ST-segment depression and clinical efficacy (P< 0.05). Adverse events were reported in 11 studies, and CHMs were well tolerated in patients with CHD. In addition, CHM exerted cardioprotection for CHD, possibly altering multiple signal pathways through anti-inflammatory, anti-oxidation, anti-apoptosis, improving the circulation, and regulating energy metabolism. In conclusion, the evidence available from present study revealed that CHMs are benefit for CHD and are generally safe.

Keywords: Traditional Chinese Medicine, coronary heart disease, high-quality randomized controlled trials, clinical evidence, Possible mechanisms, Systematic review

Received: 06 Jan 2019; Accepted: 01 Jul 2019.

Edited by:

Tie-Jun Li, Second Military Medical University, China

Reviewed by:

Amy Botta, York University, Canada
Linda Zhong, Hong Kong Baptist University, Hong Kong  

Copyright: © 2019 Zhang, Zheng, Zhu, Tong, Zhuang, Zhu, Bao, Huang, Zheng and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Guo-qing Zheng, Department of Neurology, Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China, gq_zheng@sohu.com