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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01001

Superparamagnetic oxygen-loaded nanobubbles to enhance tumor oxygenation during hyperthermia

  • 1Department of Neuroscience, School of Medicine, University of Turin, Italy
  • 2Department of Drug Science and Technology, University of Turin, Italy
  • 3Istituto Materiali per Elettronica e Magnetismo (IMEM), Italy
  • 4University of Turin, Italy

Tumor oxygenation is a critical issue for enhancing Radiotherapy (RT) effectiveness. Alternating RT with Hyperthermia (HT) improves tumor radiosensitivity by inducing a massive vasodilation of the neo-angiogenic vasculature provided the whole tumor is properly heated.
The aim of this work was the development of superparaMagnetic Oxygen-Loaded NanoBubbles (MOLNBs) as innovative theranostic hyperthermic agents to potentiate tumor oxygenation by direct intracellular oxygen administration.
MOLNBs were obtained by functionalizing dextran shelled and perfluoropentane cored nanobubbles with Superparamagnetic Iron Oxide Nanoparticles (SPIONs). MOLNBs with sizes of about 380 nm were manufactured and they were able to store oxygen and in vitro release it with prolonged kinetics.
In vitro investigation showed that MOLNBs can increase tissue temperature when exposed to Radiofrequency magnetic fields. Moreover, they are easily internalized by tumor cells, herein releasing oxygen with a sustained kinetics.
In conclusion, MOLNBs can be considered a multimodal theranostic platform since, beyond their nature of contrast agent for Magnetic Resonance Imaging (MRI) due to magnetic characteristics, they showed echogenic properties and can be visualized using medical ultrasound.

Keywords: theranostics, ultrasound, Nanobubbles, SPIONs, oxygen-, tumor, magnetic hyperthermia

Received: 19 Feb 2019; Accepted: 06 Aug 2019.

Edited by:

José Das Neves, Institute of Research and Innovation in Health, University of Porto, Portugal

Reviewed by:

Yufang Zhu, University of Shanghai for Science and Technology, China
Konstantinos Simeonidis, Aristotle University of Thessaloniki, Greece  

Copyright: © 2019 Zullino, Argenziano, Albertini, Cavalli and Guiot. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Roberta Cavalli, University of Turin, Turin, Italy,