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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01006

PHYSICO-CHEMICAL CHARACTERIZATION AND BIOPHARMACEUTICAL EVALUATION OF LIPID-POLOXAMER-BASED ORGANOGELS FOR CURCUMIN SKIN DELIVERY

  • 1Federal University of ABC, Brazil
  • 2University of Franca, Brazil
  • 3Faculdade de Medicina e Odontologia, São Leopoldo Mandic, Brazil
  • 4Instituto de Ciência e Tecnologia (Unesp), Sorocaba, Brazil
  • 5University of São Paulo, Brazil
  • 6Universidade do Estado de Minas Gerais, Brazil

Organogels (ORGs) are semi-solid materials, in which an organic phase is immobilized by a three-dimensional network composed of self-organized system, forming the aqueous phase. In this context, lipid–Pluronics (PLs) organogels form a two-phase system which can be effectively used as skin delivery systems, favoring their permeation across the skin. In this study, we presented the development of ORGs skin drug-delivery systems for curcumin (CUR), a liposoluble phenolic pigment extracted from the turmeric rhizome. In special, we designed the formulations compositions in order to carry high amounts of CUR soluble in oleic acid (OA), as organic phase, entrapped into an aqueous phase composed of micellar PL-based hydrogels by associating two polymers with different hydrophilic-lipophilic balances, Pluronic F-127 (PL F-127) and Pluronic L-81 (PL L-81), to enhance the permeation across the skin. Results revealed that the incorporation of PL L-81 favored the CUR incorporation into micelle-micelle interface. CUR insertion into OA-PL F-127/L-81 reduced both G’/G” relationship (~16 x) and viscosity values (η* ~ 54 mPa.s, at 32.5 °C), disturbing the ORGs network structural organization. In vitro permeation assays through Strat-M® skin-model membranes showed that higher CUR permeated amounts were obtained for OA-PL F-127/L-81 (4.83 µg.cm-2) compared to OA-PL F-127 (3.51 μg.cm−2) and OA (2.25 μg.cm−2) or hydrogels (~1.2 μg.cm−2, p < 0.001). Additionally, ORGs formulations presented low cytotoxic effects and evoked pronounced antileishmanial activity (IC50 < 1.25 µg.mL-1), suggesting their potential use as skin delivery systems against L. amazonensis. Results from this study pointed out OA-PL- based ORGs as promising new formulations for possible CUR topical administration.

Keywords: Oleic Acid, Curcumin, Organogels, Pluronic, skin-delivery

Received: 11 Feb 2019; Accepted: 08 Aug 2019.

Copyright: © 2019 Vigato, De Faria, Bolela Bovo Candido, Caldas, Maria Saia Cereda, Radomille Tofoli, Campos, Machado, Querobino, Fraceto, Sairre and De Araujo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Daniele R. De Araujo, Federal University of ABC, Santo André, 09210-580, São Paulo, Brazil, daniele.araujo@ufabc.edu.br