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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01012

Estrogen Receptor Related DNA and Histone Methylation May be Involved in the Transgenerational Disruption in Spermatogenesis by Selective Toxic Chemicals

Xiao Han1, Pengfei Zhang1, Wei Shen1,  Yong Zhao1* and  Hongfu Zhang2
  • 1Qingdao Agricultural University, China
  • 2Chinese Academy of Agricultural Sciences, China

Air pollution is a global threat to human health especially spermatogenesis. Animal and epidemiological studies suggest that epigenetic factors can transmit the pathologies transgenerationally. Paternal epigenetic effects can greatly impact on the offspring health. In this study and together with our previous report, we found that H2S donor Na2S and/or NH3 donor NH4Cl diminished mouse fertility, decreased spermatozoa concentration and motility, and impaired spermatogenesis in three consequent generations (F0, F1, and F2). In current study, we found that DNA methylation, histone methylation, and estrogen receptor alpha (ER) were impaired by NH4Cl and/or Na2S in F0, F1 and F2 mouse testes. Moreover, NH4Cl and/or Na2S might act as environmental endocrine disrupting chemicals to decrease estrogen and testosterone in mouse blood. It has been reported that ER signaling is intertwined together with DNA methylation and histone methylation which plays very important roles in spermatogenesis. These data together indicate that the transgenerational disruption in spermatogenesis by NH4Cl and/or Na2S may be through ER related DNA methylation and histone methylation pathways. Therefore, we strongly recommend that greater attention should be paid to NH3 and/or H2S contamination to minimize their impact on human health especially spermatogenesis.

Keywords: Spermatogenesis, Transgenernational, DNA Methylation, Histone Methylation, estrogen signaling, NH3

Received: 31 May 2019; Accepted: 08 Aug 2019.

Edited by:

Salvatore Salomone, University of Catania, Italy

Reviewed by:

Md Saidur Rahman, Department of Animal Science and Technology, Chung-Ang University, South Korea
Myung-Geol Pang, Chung-Ang University, South Korea  

Copyright: © 2019 Han, Zhang, Shen, Zhao and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Yong Zhao, Qingdao Agricultural University, Qingdao, China, yzhao818@hotmail.com