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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01022

N-3 polyunsaturated fatty acids and the resolution of neuroinflammation

 Corinne Joffre1, 2*, Charlotte Rey1, 2, 3 and  Sophie Laye1, 2
  • 1INRA Centre Bordeaux-Aquitaine, France
  • 2Université de Bordeaux, France
  • 3Institut des Corps Gras, France

In the past few decades, as a result of their anti-inflammatory properties, n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), have gained greater importance in the regulation of inflammation, especially in the central nervous system (in this case known as neuroinflammation). If sustained, neuroinflammation is a common denominator of neurological disorders, including Alzheimer’s disease and major depression, and of aging. Hence, limiting neuroinflammation is a real strategy for neuroinflammatory disease therapy and treatment. Recent data show that n-3 LC-PUFAs exert anti-inflammatory properties in part through the synthesis of specialized pro-resolving mediators (SPMs) such as resolvins, maresins and protectins. These SPMs are crucially involved in the resolution of inflammation. They could be good candidates to resolve brain inflammation and to contribute to neuroprotective functions and could lead to novel therapeutics for brain inflammatory diseases. This review presents an overview 1) of brain n-3 LC-PUFAs as precursors of SPMs with an emphasis on the effect of n-3 PUFAs on neuroinflammation, 2) of the formation and action of SPMs in the brain and their biological roles, and the possible regulation of their synthesis by environmental factors such as inflammation and nutrition and, in particular, PUFA consumption.

Keywords: n-3 long-chain polyunsaturated fatty acids (LCPUFA), Docosahexaenoic acid - DHA, Eicosapentaenoic acid - EPA, Specialized pro-resolving lipid mediator (SPM), nutrition, Neuroinflammation, Resolvins

Received: 21 Mar 2019; Accepted: 12 Aug 2019.

Copyright: © 2019 Joffre, Rey and Laye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Corinne Joffre, INRA Centre Bordeaux-Aquitaine, Bordeaux, France, corinne.joffre@inra.fr