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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01096

Neuroprotective effects and mechanisms of Zhenlong Xingnao Capsule in in vivo and in vitro models of hypoxia

 Peng Sun1*,  Xia Wei2,  Qingfen Zhu2,  Na Liu2, Lihua Xu2,  Sheng Wei1, Zhiyun Fan2, Changhua Sun2, Yan Zhao2,  Mingqi Qiao1, Jibiao Wu1,  Defu Hu2* and  Yang Wang3*
  • 1Shandong University of Traditional Chinese Medicine, China
  • 2Shandong Institutes for Food and Drug Control, China
  • 3Xiangya Hospital, Central South University, China

Zhenlong Xingnao Capsule (ZXC) is a Tibetan medicine used to treat ischemic stroke. We aimed to clarify the role of ZXC in cerebral ischemia protection; reveal amino acid neurotransmitter changes in the frontal cortex after drug intervention; determine mRNA and protein expression changes in Bcl-2, Bax, caspase-3, P38, and nuclear factor (NF)-кB in the frontal cortex and changes in antioxidant indices in the brain; and elucidate the mechanisms underlying ZXC action.

Keywords: Zhenlong Xingnao Capsule, Middle cerebral artery occlusion model, Cerebral ischemia-reperfusion injury, Reactive Oxygen Species, BV-2 cell

Received: 14 Feb 2019; Accepted: 26 Aug 2019.

Copyright: © 2019 Sun, Wei, Zhu, Liu, Xu, Wei, Fan, Sun, Zhao, Qiao, Wu, Hu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Peng Sun, Shandong University of Traditional Chinese Medicine, Jinan, China, sunpeng@sdutcm.edu.cn
Dr. Defu Hu, Shandong Institutes for Food and Drug Control, Jinan, 250101, Shandong Province, China, hudefu@sdfda.gov.cn
Dr. Yang Wang, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China, wangyang_xy87@163.com