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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01110

Downregulation of Wnt3 suppresses colorectal cancer development through inhibiting cell proliferation and migration

Xiaobo Nie1, Fulin Xia1, Ying Liu1, Yun Zhou1, Wenling Ye1, Panha Hean2, Jiming Meng Meng2, Huiyang Liu1, Jianxun Wen3, Xuequn Ren2,  Wei-Dong Chen1 and  YAN-DONG WANG4*
  • 1Henan University, China
  • 2Henan University Huaihe Hospital, China
  • 3Inner Mongolia Medical University, China
  • 4Beijing University of Chemical Technology, China

The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC). Herein, we show that Wnt3 is upregulated in human CRC tissues and cell lines, and is essential for the CRC progression. Knockdown of Wnt3 in human colorectal cancer cells delayed tumor formation in nude mouse xenografts through silencing of canonical Wnt pathway and glycolysis. We further found that silencing of Wnt3 enhanced the sensitivity of CRC cells to cisplatin through inducing apoptotic cell death. Taken together, it demonstrates that Wnt3 is a novel clinical biomarker for the detection of CRC and plays an important role in colorectal tumorigenesis. Therefore, downregulation of Wnt3 will be a valuable strategy in CRC treatment.

Keywords: Wnt3, colorectal cancer, HCT-116 cell, proliferation, Apoptosis, Glycolysis

Received: 07 May 2019; Accepted: 29 Aug 2019.

Copyright: © 2019 Nie, Xia, Liu, Zhou, Ye, Hean, Meng, Liu, Wen, Ren, Chen and WANG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. YAN-DONG WANG, Beijing University of Chemical Technology, Beijing, China, ydwangbuct2009@163.com