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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01134

Protective effect of patchouli alcohol against high-fat diet induced hepatic steatosis by alleviating endoplasmic reticulum stress and regulating VLDL metabolism in rats

 Xue Wu1, Nan Xu1,  Minyao Li1, Qionghui Huang1, Jiazhen Wu1, Yuxuan Gan1, Liping Chen2, Huijuan Luo1,  Yucui Li1, Xiaoqi Huang1,  Ziren Su1* and  Yuhong Liu1*
  • 1Guangzhou University of Chinese Medicine, China
  • 2Sun Yat-sen University, China

Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic hepatic disorder worldwide. The earliest stage of NAFLD is simple steatosis, which is characterized by the accumulation of triglycerides in hepatocytes. Inhibition of steatosis is a potential treatment for NAFLD. Patchouli alcohol (PA) is an active component of Pogostemon cablin (Blanco) Benth. (Labiatae), which is a medicinal food in Asia countries and proved to possess hepatoprotective effect. This research aimed to investigate the effectiveness of PA against high fat diet (HFD)-induced hepatic steatosis in rats. In this study, male Sprague Dawley rats were fed a HFD for 4 weeks to induce NAFLD. Oral administration with PA significantly reduced pathological severity of steatosis in HFD-fed rats. It was associated with suppressing endoplasmic reticulum (ER) stress and regulating very low-density lipoprotein (VLDL) metabolism. Our data showed that PA treatment effectively attenuated ER stress by inhibiting the activation of protein kinase-like ER kinase (PERK), inositol-requiring transmembrane kinase/endoribonuclease 1(IRE1) and activating transcription factor 6 (ATF6). Moreover, PA decreased hepatic VLDL uptake by suppressing very low-density lipoprotein receptor (VLDLR) expression. It also restored VLDL synthesis and export by increasing apolipoprotein B100 (apoB 100) secretion and microsomal triglyceride-transfer protein (MTP) activity. Taken together, PA exerted a protective effect on the treatment of NAFLD in HFD-fed rats and may be potential therapeutic agent acting on hepatic steatosis.

Keywords: Patchouli alcohol, nonalcoholic fatty liver disease, Hepatic Steatosis, Very low-density lipoprotein, Endoplasmic Reticulum Stress

Received: 01 Jun 2019; Accepted: 02 Sep 2019.

Copyright: © 2019 Wu, Xu, Li, Huang, Wu, Gan, Chen, Luo, Li, Huang, Su and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Ziren Su, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong Province, China, suziren@gzucm.edu.cn
Dr. Yuhong Liu, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong Province, China, liuyuhong@gzucm.edu.cn