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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01137

Employing parasite against cancer: a lesson from the canine tapeworm Echinococcus granulocus

Xiao Wang1,  Wang Guan1, Xiaoqin Zhang2* and Jinxin Zhang3*
  • 1Sichuan Cancer Hospital, China
  • 2Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, China
  • 3Sun Yat-sen University, China

Cystic echinococcosis (CE), a devastating zoonotic condition caused by the tapeworm Echinococcus granulosus, remain a significant public health problem worldwide. However, after a negative correlation between solid tumor and CE has been incidentally discovered, accumulating evidences have suggested that this parasite may induce anti-cancer effect through activating host immune response and secreting molecules with anti-cancer potential, which may provide some new understanding for immunotherapy. This article will review the evidences supporting the anti-cancer effect of E. granulosus and its underlying mechanisms, and discuss the possible implications in immunotherapy.

Keywords: Echinococcus granulosus, Cancer, Immunotherapy, immune response, adjuvant

Received: 24 Jun 2019; Accepted: 03 Sep 2019.

Copyright: © 2019 Wang, Guan, Zhang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Xiaoqin Zhang, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, doczxq@163.com
Prof. Jinxin Zhang, Sun Yat-sen University, Guangzhou, 510275, Guangdong Province, China, zhjinx@mail.sysu.edu.cn