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Front. Pharmacol. | doi: 10.3389/fphar.2019.01222

Isobologram analysis: A Comprehensive Review of Methodology and Current Research

 Ruo-yue Huang1, Lin-lin Pei1, Quan-jin Liu1, Shi-qi Chen1, Hai-bo Dou1, Gang Shu1,  Zhi-xiang Yuan1, Ju-chun Lin1, Guang-neng Peng1, Wei Zhang1 and Hua-lin Fu1*
  • 1Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, China

Drug combination is a common method for clinical disease treatment. Whether the combination of drugs is reasonable often affects the result of the disease treatment. Many methods have been used to evaluate interaction between drugs to date. Isobologram analysis has been mathematically proven and widely used to evaluate drug interactions. In this paper, the principle of isobologram analysis and its application in drug interaction evaluation are summarized. The applications of the similar cotoxicity coefficient and fractional inhibitory concentration index in the evaluation of drug interaction are also reviewed. This work is expected to evaluate the effect of formulations scientifically and provide scientific judgment standards for the development of formulations and clinical drug compatibility.

Keywords: application, principle, Isobologram analysis, Synergy, Drug Interaction

Received: 26 May 2019; Accepted: 23 Sep 2019.

Copyright: © 2019 Huang, Pei, Liu, Chen, Dou, Shu, Yuan, Lin, Peng, Zhang and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mr. Hua-lin Fu, Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Chengdu, Sichuan Province, China,