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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01253

The TRPA1 channel in the cardiovascular system: promising features and challenges

 Jun Wan1*,  Zhen Wang1, Jing Ye1, Di Ye1, Menglong Wang1, Jianfang Liu2, Huimin Jiang2, Yao Xu2, Jishou Zhang2 and Jiangbin Chen1
  • 1Renmin Hospital, Faculty of Medical Sciences, Wuhan University, China
  • 2Renmin Hospital of Wuhan University, China

Abstract: The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily. Recent studies have suggested that the TRPA1 channel plays an essential role in the development and progression of several cardiovascular conditions, such as atherosclerosis, heart failure, myocardial ischemia-reperfusion injury (IRI), myocardial fibrosis, arrhythmia, vasodilation and hypertension. Activation of the TRPA1 channel has a protective effect against the development of atherosclerosis and myocardial IRI. Furthermore, TRPA1 channel activation elicits myocardium contractility and peripheral vasodilation. Moreover, activation of the TRPA1 channel induces a biphasic blood pressure response. However, loss of channel expression or blockade of its activation suppresses myocardial fibrosis and arrhythmia. In this paper, we review the recent progress of research on the TRPA1 channel and discuss its dual role in the cardiovascular system.

Keywords: TRPA1, Atherosclerosis, Heart Failure, Myocardial ischemia-reperfusion injury, Myocardial fibrosis, arrhythmia, Vasodilation, Hypertension

Received: 07 Jul 2019; Accepted: 27 Sep 2019.

Copyright: © 2019 Wan, Wang, Ye, Ye, Wang, Liu, Jiang, Xu, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Jun Wan, Renmin Hospital, Faculty of Medical Sciences, Wuhan University, Wuhan, Hubei Province, China, wanjun@whu.edu.cn