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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01301

HeteroDualNet: A dual convolutional neural network with heterogeneous layers for drug-disease association prediction

 Hui Cui1, Tonghui Shen2, Nan Sheng2, Tiangang Zhang2 and Ping Xuan2*
  • 1La Trobe University, Australia
  • 2Heilongjiang University, China

Identifying new treatments for existing drugs can help reduce drug development costs and explore novel indications of drugs. The prediction of associations between drugs and diseases is challenging because their similarities and relations are complicated and non-linear. We propose a HeteroDualNet model to address this issue. Firstly, three types of matrices are extracted to represent intra-drug similarities, intra-disease similarity and drug-disease associations. The intra-drug similarities consider three drug features and a newly introduced drug-related disease correlation. Secondly, an embedding mechanism is proposed to integrate these matrices in a heterogenous drug-disease association layer (hetero-layer). Further, a neighbouring heterogeneous layer (hetero-layer-N) is constructed to incorporate the biological premise that similar drugs can often treat related diseases. Finally, a dual convolutional neural network is built with hetero-layer and hetero-layer-N as two branches to learn from characteristics of drug-disease and the relations of their neighbours simultaneously. HeteroDualNet outperformed the other four methods in comparison over a public dataset of 763 drugs and 681 diseases in terms of Areas Under the Curves of Receiver Operating Characteristics and Precision-Recall, and recall rate at top k. Case study of five drugs further proved the capacity of HeteroDualNet in finding reliable disease candidates of drugs as validated by database records or literature. Our findings show that the embedded heterogenous layers of original and neighbouring drug-disease representations in a dual neural network improved the association prediction performance.

Keywords: deep learning, multiple kinds of similarities, neighbouring heterogeneous layer, Drug-disease association prediction, Convolutional neural network (CNN)

Received: 01 Jul 2019; Accepted: 11 Oct 2019.

Copyright: © 2019 Cui, Shen, Sheng, Zhang and Xuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Ping Xuan, Heilongjiang University, Harbin, 130012, Heilongjiang Province, China,