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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01352

Emerging Roles for NLRC5 in Immune Diseases

Jie-Quan Wang1, Ya-Ru Liu2, Quan Xia2, Ruo-Nan Chen2, Jun Liang1, Qing-Rong Xia1 and  Jun Li3*
  • 1Hefei Fourth People's Hospital, China
  • 2First Affiliated Hospital of Anhui Medical University, China
  • 3Anhui Medical University, China

Innate immune activates the corresponding immune response, requiring identification of pathogens by multiple pattern recognition receptors (PRRs), like NOD-like receptors (NLRs). To our knowledge, NLRs are a large protein family of pattern recognition receptors in the cytoplasm, which involved in inflammatory diseases and promoted the rapid clearance of invasive pathogens. Additionally, NLRC5 is the largest member of NLRs, participating in immune responses repeatedly. Notably, the expression of NLRC5 increased significantly in immune cells and immune-related tissues. Nevertheless, the evidence for higher expression of NLRC5 in immune disease is inconsistent. Furthermore, there is growing evidence that NLRC5 was involved in the innate immune response and inflammatory diseases. NLRC5 has been confirmed to exert a critical role in the control of regulatory diverse signaling pathways. In particular, NLRC5 broadly participated in the occurrence and development of immune diseases, which is a potential therapeutic target. However, in order to develop targeting drugs, a more profound understanding of intrinsic characteristic and underlying mechanisms of NLRC5 is necessary. Herein, current knowledge of NLRC5 is summarized, and research advances of NLRC5 in the characteristic, biological function and regulation mechanisms are reviewed.

Keywords: NLRC5, NLRs, Immune diseases, biological functions, Signaling Pathways

Received: 13 Aug 2019; Accepted: 25 Oct 2019.

Copyright: © 2019 Wang, Liu, Xia, Chen, Liang, Xia and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Jun Li, Anhui Medical University, Hefei, China, lijunahmu@163.com