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Front. Pharmacol. | doi: 10.3389/fphar.2019.01355

Therapeutical Effects of Natural Drug on Alzheimer Disease

 Shulong Yang1*,  Yuan Ma1,  Man-Wen Yang1, Xin-Wei Li1,  Jian-Wei Yue1, Jun-Zong Chen1, Mei-Wen Yang1, Xuan Huang1, Lian-Lian Zhu1 and Fenfang Hong2
  • 1Nanchang University, China
  • 2Medical Experimental Teaching Center, Nanchang University, China

Alzheimer disease (AD) is characterised as a kind of chronic neurodegenerative disease which is associated with age. And its clinical manifestations are composed of latent episodes of memory and cognitive impairment, psychiatric symptoms and behavioral disorders as well as limited activities in daily life. In the developed countries, AD is now acknowledged as the third leading reason of death, only second to the cardiovascular disease and cancer. The pathogenesis and mechanism of AD are still unclear now, although there are already some theories to explore AD, such as β-amyloid theory, the theory of abnormal metabolism of tau protein, the theory of free radical damage, the theory of inflammatory response and cholinergic damage theory and etc. There are still no effective ways to predict, prevent or reverse AD, so developing new efficient therapeutic drug becomes a global hot spot currently. Isolating and extracting active component from natural drug has great potential in treating AD, which presents the advantages of multiple target point, multi-pathway, less side effects and long duration of curative effect. This essay summaries the latest research progresses of natural drug mechanisms in the treatment of AD, providing literature and theoretical basis for better clinical treatment of AD.

Keywords: Alzheimer Disease, β-Amyloid, Natural drug, tau protein metabolism, Free radical damage

Received: 30 May 2019; Accepted: 25 Oct 2019.

Copyright: © 2019 Yang, Ma, Yang, Li, Yue, Chen, Yang, Huang, Zhu and Hong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Shulong Yang, Nanchang University, Nanchang, China, shulongyang@qq.com