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Front. Pharmacol. | doi: 10.3389/fphar.2019.01400

Review of Siraitia grosvenorii: a special fruit of medicine food homology in China

  • 1Baotou Medical College, China
  • 2Inner Mongolia Autonomous Region Academy of Chinese Medicine, China
  • 3Agricultural College, Inner Mongolia University for Nationalities, China
  • 4Guangxi Medicinal Botanical Garden, China
  • 5Other, China
  • 6Inner Mongolia Medical University, China

Siraitia grosvenorii (Swingle) C. Jeffrey, a member of the family Cucurbitaceae, is a unique economic and medicinal plant grown in China. For more than 300 years, S. grosvenorii has been used as a natural sweetener and as a traditional medicine for the treatment of pharyngitis, pharyngeal pain, as well as an anti-tussive remedy in China. It is one of the first approved medicine food homology species in China. It has been widely studied as a natural product with high development potential. Therefore, the present paper provides a review of the botanical characterization, traditional uses and ethnopharmacology, food and nutritional values, chemical constituents, pharmacological effects, toxicology, and development direction for the future of S. grosvenorii. Phytochemical studies have revealed that the chemical composition of this plant mainly includes iridoid and phenylpropanoid glycosides. Several compounds such as triterpenoids, flavonoids, and amino acids have been isolated from the plant. S. grosvenorii and its active constituents possess broad pharmacological properties, such as antioxidant, hypoglycemic, immunologic, anti-tussive and sputum-reducing, hepatoprotective, and antimicrobial activities, etc. By documenting the comprehensive information of S. grosvenorii, we hope to establishes the groundwork for further research on the mechanism of action of S. grosvenorii and its development as a new health food in the future.

Keywords: Siraitia grosvenorii, Ethnopharmacology, food and nutritional value, Chemical constituent, antioxidant

Received: 12 May 2019; Accepted: 01 Nov 2019.

Copyright: © 2019 Gong, Chen, Ren, Jia, Wei, Zhang, Lv, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mx. Jianhua Wang, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China, ny_wjh513@163.com
Prof. Minhui Li, Baotou Medical College, Baotou, 014040, China, prof_liminhui@yeah.net